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dc.contributor.authorJohannessen, Aneen_US
dc.contributor.authorLønnebotn, Marianneen_US
dc.contributor.authorCalciano, Luciaen_US
dc.contributor.authorBenediktsdóttir, Bryndísen_US
dc.contributor.authorBertelsen, Randi Jacobsenen_US
dc.contributor.authorBråbäck, Lennarten_US
dc.contributor.authorDharmage, Shyamalien_US
dc.contributor.authorFranklin, Karl A.en_US
dc.contributor.authorGíslason, Þórarinnen_US
dc.contributor.authorHolm, Mathiasen_US
dc.contributor.authorJanson, Christeren_US
dc.contributor.authorJarvis, Deborahen_US
dc.contributor.authorJõgi, Rainen_US
dc.contributor.authorKim, Jeong-Limen_US
dc.contributor.authorKirkeleit, Jorunnen_US
dc.contributor.authorLodge, Carolineen_US
dc.contributor.authorMalinovschi, Andreien_US
dc.contributor.authorMartinez-Moratalla, Jesusen_US
dc.contributor.authorNilsen, Roy Miodinien_US
dc.contributor.authorPereira-Vega, Antonioen_US
dc.contributor.authorGomez Real, Franciscoen_US
dc.contributor.authorSchlünssen, Vivien_US
dc.contributor.authorAccordini, Simoneen_US
dc.contributor.authorSvanes, Cecilieen_US
dc.PublishedJohannessen A, Lønnebotn M, Calciano L, Benediktsdóttir B, Bertelsen RJ, Bråbäck L, Dharmage S, Franklin KA, Gíslason Þ, Holm M, Janson C, Jarvis D, Jõgi R, Kim J, Kirkeleit J, Lodge C, Malinovschi A, Martinez-Moratalla, Nilsen RM, Pereira-Vega A, Gomez Real F, Schlünssen V, Accordini S, Svanes C. Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?. Journal of Allergy and Clinical Immunology. 2019:145(3)eng
dc.description.abstractBackground Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectAgeing Lungs in European Cohorts studyeng
dc.subjectmultilevel mediation modeleng
dc.subjectparental risk factorseng
dc.titleBeing overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalJournal of Allergy and Clinical Immunology

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