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dc.contributor.authorJohnston, Iain George
dc.contributor.authorBurgstaller, Joerg
dc.PublishedJohnston IG, Burgstaller JP. Evolving mtDNA populations within cells. Biochemical Society Transactions. 2019;47:1367eng
dc.description.abstractMitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and other population processes. These processes affect the genetic makeup of cellular mtDNA populations, changing cell-to-cell distributions, means, and variances of mutant mtDNA load over time. As mtDNA mutant load has nonlinear effects on cell functionality, and cell functionality has nonlinear effects on tissue performance, these statistics of cellular mtDNA populations play vital roles in health, disease, and inheritance. This mini review will describe some of the better-known ways in which these populations change over time in different organisms, highlighting the importance of quantitatively understanding both mutant load mean and variance. Due to length constraints, we cannot attempt to be comprehensive but hope to provide useful links to some of the many excellent studies on these topics.en_US
dc.publisherPortland Pressen_US
dc.rightsAttribution CC BYeng
dc.titleEvolving mtDNA populations within cellsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.source.journalBiochemical Society Transactions

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