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dc.contributor.authorBorgen, Tove Tveitanen_US
dc.contributor.authorBjørnerem, Åshilden_US
dc.contributor.authorSolberg, Lene Bergendalen_US
dc.contributor.authorAndreasen, Camillaen_US
dc.contributor.authorBrunborg, Cathrineen_US
dc.contributor.authorStenbro, May-Britten_US
dc.contributor.authorHübschle, Lars Michaelen_US
dc.contributor.authorFroholdt, Anneen_US
dc.contributor.authorFigved, Wenderen_US
dc.contributor.authorApalset, Ellen Men_US
dc.contributor.authorGjertsen, Jan-Eriken_US
dc.contributor.authorBasso, Trudeen_US
dc.contributor.authorLund, Idaen_US
dc.contributor.authorHansen, Ann Kristinen_US
dc.contributor.authorStutzer, Jens-Meinharden_US
dc.contributor.authorDahl, Cecilieen_US
dc.contributor.authorOmsland, Tone Kristinen_US
dc.contributor.authorNordsletten, Larsen_US
dc.contributor.authorFrihagen, Frede Jonen_US
dc.contributor.authorEriksen, Erik Finken_US
dc.PublishedBorgen TT, Bjørnerem Å, Solberg LB, Andreasen C, Brunborg C, Stenbro, Hübschle LM, Froholdt A, Figved W, Apalset EM, Gjertsen JE, Basso T, Lund, Hansen AK, Stutzer J, Dahl C, Omsland TK, Nordsletten L, Frihagen FJ, Eriksen EF. High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT. Bone. 2019;122:14-21eng
dc.description.abstractPurpose: Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with fragility fractures, their prevalence of vertebral fractures using VFA and prevalence of low TBS, and explore the differences between the sexes and patients with and without vertebral fractures. Methods: This cross-sectional sub-study of the Norwegian Capture the Fracture Initiative (NoFRACT) included 839 patients with fragility fractures. Of these, 804 patients had bone mineral density (BMD) of the total hip, femoral neck and/or spine assessed using dual energy x-ray absorptiometry, 679 underwent concomitant VFA, 771 had TBS calculated and 696 responded to a questionnaire. Results: Mean age was 65.8 (SD 8.8) years and 80.5% were women. VFA revealed vertebral fractures in 34.8% of the patients and 34.0% had low TBS (≤ 1.23), with no differences between the sexes. In all patients with valid measures of both VFA and TBS, 53.8% had either vertebral fractures, low TBS, or both. In the patients with osteopenia at the femoral neck, 53.6% had either vertebral fractures, low TBS, or both. Femoral neck BMD T-score ≤ −2.5 was found in 13.8% of all patients, whereas the corresponding figure was 27.4% using the skeletal site with lowest T-score. Women exhibited lower BMD at all sites and lower TBS than men (1.27 vs. 1.29), (all p < 0.05). Patients with prevalent vertebral fractures were older (69.4 vs. 64.0 years), exhibited lower BMD at all sites and lower TBS (1.25 vs.1.29) than those without vertebral fractures (all p < 0.05). Before assessment, 8.2% were taking anti-osteoporotic drugs (AOD), and after assessment, the prescription rate increased to 56.2%. Conclusions: More than half of the patients with fragility fractures had vertebral fractures, low TBS or both. The prescription of AOD increased seven fold from before assessment to after assessment, emphasizing the importance of risk assessment after a fragility fracture.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.titleHigh prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACTen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)

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