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dc.contributor.authorKirkeleit, Jorunnen_US
dc.contributor.authorRiise, Tronden_US
dc.contributor.authorGjertsen, Bjørn Toreen_US
dc.contributor.authorMoen, Bente E.en_US
dc.contributor.authorBråtveit, Magneen_US
dc.contributor.authorBruserud, Øysteinen_US
dc.PublishedThe Open Hematology Journal 2: 87-102en_US
dc.description.abstractBenzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.en_US
dc.publisherBentham Openeng
dc.rightsAttribution CC BYeng
dc.titleEffects of Benzene on human hematopoiesisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright Kirkeleit et al.; Licensee Bentham Open.
dc.rights.holderKirkeleit et al.
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775eng

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