dc.contributor.author | Kirkeleit, Jorunn | en_US |
dc.contributor.author | Riise, Trond | en_US |
dc.contributor.author | Gjertsen, Bjørn Tore | en_US |
dc.contributor.author | Moen, Bente E. | en_US |
dc.contributor.author | Bråtveit, Magne | en_US |
dc.contributor.author | Bruserud, Øystein | en_US |
dc.date.accessioned | 2011-02-09T14:04:31Z | |
dc.date.available | 2011-02-09T14:04:31Z | |
dc.date.issued | 2008 | eng |
dc.Published | The Open Hematology Journal 2: 87-102 | en_US |
dc.identifier.issn | 1874-2769 | |
dc.identifier.uri | https://hdl.handle.net/1956/4487 | |
dc.description.abstract | Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Bentham Open | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/ | eng |
dc.title | Effects of Benzene on human hematopoiesis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright Kirkeleit et al.; Licensee Bentham Open. | |
dc.rights.holder | Kirkeleit et al. | |
dc.identifier.doi | https://doi.org/10.2174/1874276900802010087 | |
dc.identifier.cristin | 501346 | |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 | eng |