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External quality assessment of point-of-care International Normalized Ratio (INR) testing in Europe

Stavelin, Anne; Meijer, Piet; Kitchen, Dianne; Sandberg, Sverre
Peer reviewed, Journal article
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URI
https://hdl.handle.net/1956/7606
Date
2011-09
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  • Department of Global Public Health and Primary Care [1908]
Original version
https://doi.org/10.1515/cclm.2011.719
Abstract
Background: Point-of-care testing (POCT) of prothrombin time, expressed as International Normalized Ratio (INR), is widely used to monitor patients in oral anticoagulation treatment. Guidelines recommend that POCT users should participate in an external quality assessment (EQA) scheme whenever available. The aim of this study was to investigate which European countries provide EQA for POCT INR and to compare how these schemes are organized. Methods: Thirty European countries were invited to participate in this study. Those who reported that they provide EQA for POCT INR filled in a questionnaire dealing with different aspects of their schemes. Results: Nineteen countries reported that they do not provide EQA for POCT INR, while 12 organizations from nine countries reported that they provide this service. Most of these countries circulate lyophilized samples with for the participants unknown target values. Samples with certified INR values and procedures using split samples with fresh patient samples are also used. The acceptability limits vary from 15% to 30%, and the total number of samples circulated per year varies from 1 to 12. Most of the countries organize educational activities together with their schemes. Conclusions: This study demonstrates that there is a wide variation in the way EQA for POCT INR is performed in Europe and that there are many European countries that do not provide this service. Even though our findings indicate that EQA for POCT INR draws some challenges, especially in providing suitable control materials, participation in such schemes is considered useful.
Publisher
Walter de Gruyter
Journal
Clinical Chemistry and Laboratory Medicine
Copyright
Copyright 2011 by Walter de Gruyter

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