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dc.contributor.authorBrunner, Iris Charlotteen_US
dc.contributor.authorSkouen, Jan Stureen_US
dc.contributor.authorHofstad, Håkonen_US
dc.contributor.authorStrand, Liv Ingeren_US
dc.contributor.authorBecker, Franken_US
dc.contributor.authorSanders, Anne-Martheen_US
dc.contributor.authorPallesen, Hanneen_US
dc.contributor.authorKristensen, Toveen_US
dc.contributor.authorMichielsen, Marcen_US
dc.contributor.authorVerheyden, Geerten_US
dc.description.abstractBackground: Novel virtual reality rehabilitation systems provide the potential to increase intensity and offer challenging and motivating tasks. The efficacy of virtual reality systems to improve arm motor function early after stroke has not been demonstrated yet in sufficiently powered studies. The objective of the study is to investigate whether VR training as an adjunct to conventional therapy is more effective in improving arm motor function in the subacute phase after stroke than dose-matched conventional training, to assess patient and therapist satisfaction when working with novel virtual reality training and to calculate cost-effectiveness in terms of resources required to regain some degree of dexterity. Methods/Design: Randomized controlled observer-blind trial. One hundred and twenty patients up to 12 weeks after stroke will be randomized to either a group receiving VR training or dose-matched and therapist attention-matched conventional arm training in addition to standard rehabilitation. During a period of four weeks the patients will be offered additional 4–5 training sessions a week of 45–60 minutes duration by a physiotherapist or an occupational therapist. Study outcomes: Arm motor function, dexterity and independence in daily life activities will be evaluated at baseline, post treatment and three months follow-up assessments with the Action Research Arm Test, Box and Blocks Test and the Functional Independence Measure, respectively. Patient and therapist satisfaction with the implementation of a VR rehabilitation system will also be assessed with questionnaires and interviews. Discussion: Virtual reality systems are promising tools for rehabilitation of arm motor function after stroke. Their introduction in combination with traditional physical and occupational therapy may enhance recovery after stroke, and at the same time demand little personnel resources to increase training intensity. The VIRTUES trial will provide further evidence of VR-based treatment strategies to clinicians, patients and health economists.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectVirtual realityeng
dc.subjectUpper extremityeng
dc.subjectMotor functioneng
dc.subjectPhysical therapyeng
dc.subjectOccupational therapyeng
dc.titleVirtual reality training for upper extremity in subacute stroke (VIRTUES): study protocol for a randomized controlled multicenter trialen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 Brunner et al.; licensee BioMed Central Ltd.
dc.rights.holderIris Brunner et al.; licensee BioMed Central Ltd.
dc.source.journalBMC Neurology

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