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dc.contributor.authorLeirgul, Elisabethen_US
dc.contributor.authorFomina, Tatianaen_US
dc.contributor.authorBrodwall, Kristofferen_US
dc.contributor.authorGreve, Gottfrieden_US
dc.contributor.authorHolmstrøm, Henriken_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorTell, Grethe Seppolaen_US
dc.contributor.authorØyen, Ninaen_US
dc.date.accessioned2014-12-29T09:21:57Z
dc.date.available2014-12-29T09:21:57Z
dc.date.issued2014-08-10eng
dc.identifier.issn0002-8703
dc.identifier.urihttps://hdl.handle.net/1956/9040
dc.description.abstractBackground The reasons for decreasing birth prevalence of congenital heart defects (CHDs) in several European countries and Canada are not fully understood. We present CHD prevalence among live births, stillbirths, and terminated pregnancies in an entire nation over a period of 16 years. Methods Information on all births in the Medical Birth Registry of Norway, 1994-2009, was updated with information on CHD from the hospitals' Patient Administrative Systems, the National Hospital's clinical database for children with heart disease, and the Cause of Death Registry. Individuals with heart defects were assigned specific cardiac phenotypes. Results Among 954,413 births, 13,081 received a diagnosis of CHD (137.1 per 10,000 births, 133.2 per 10,000 live births). The prevalence per 10,000 births was as follows: heterotaxia, 1.6; conotruncal defects, 11.6; atrioventricular septal defects, 5.6; anomalous pulmonary venous return, 1.1; left outflow obstructions, 8.7; right outflow obstructions, 5.6; septal defects, 65.5; isolated patent ductus arteriosus, 24.6; and other specified or unspecified CHD, 12.7. Excluding preterm patent ductus arteriosus, the CHD prevalence was 123.4 per 10,000; per year, the prevalence increased with 3.5% (95% CI 2.5-4.4) in 1994-2005 and declined with 9.8%(−16.7 to −2.4) from2005 onwards. SevereCHDprevalencewas 30.7 per 10,000; per-year increase was 2.3% (1.1-3.5) in 1994-2004, and per-year decrease was 3.4% (−6.6 to −0.0) in 2004-2009. Numbers included severe CHD in stillbirths and terminated pregnancies. Conclusions The birth prevalence of CHD declined from around 2005. Specifically, the prevalence of severe CHD was reduced by 3.4% per year from 2004 through 2009. (Am Heart J 2014;168:956-64.)en_US
dc.language.isoengeng
dc.publisherElseviereng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.titleBirth prevalence of congenital heart defects in Norway 1994-2009—A nationwide studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 The Authors
dc.identifier.doihttps://doi.org/10.1016/j.ahj.2014.07.030
dc.identifier.cristin1210250
dc.source.journalAmerican Heart Journal
dc.source.40168
dc.source.146
dc.source.pagenumber956-964


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