Blar i Department of Biological Sciences på emneord "759929"
Viser treff 1-20 av 36
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Actin N-terminal acetylation impacts cell adhesion and invasion
(Master thesis, 2019-12-14) -
An optogenetic investigation of contractile forces and its effect on CNS development in Ciona intestinalis
(Master thesis, 2024-06-03) -
Antiviral immune responses in lumpfish (Cyclopterus lumpus) - with emphasis on type I interferons
(Master thesis, 2021-06-01) -
BRCA1 promoter methylation: the influence on gene expression and the effect of long term drug treatment
(Master thesis, 2017-07-04)Breast cancer is the most common type of cancer among woman all over the world, with over 1.67 million new cases in 2012. Heritable breast cancer is closely linked to mutations in the tumor suppressor gene BRCA1, with up ... -
Brd4 as a candidate protein for the recognition of histone H3 lysine 27 acetylation
(Master thesis, 2015-06-29)Post-translational modifications (PTMs) of histone tails are associated with the regulation of transcriptional processes. Patterns of histone modifications mark regions of high or low transcriptional activity, and are ... -
Ca^2+-signalling in C. intestinalis notochord cells during embryonic development
(Master thesis, 2018-05-10)C. intestinalis notochord is an essential structure during embryonic development, conveying position and fate information, in addition to serving as a structural support and enabling locomotion during larval stage. Researchers ... -
Characterization of CD4+ T-Cell Subsets and Responses in Lumpfish (Cyclopterus lumpus).
(Master thesis, 2022-06-01) -
Characterization of insertion variants of the carboxyl-ester lipase (CEL) gene - A role in pancreatic disease?
(Master thesis, 2018-06-26)Carboxyl ester lipase (CEL) is a digestive enzyme that is mainly expressed in the acinar cells of the pancreas. The CEL gene is highly polymorphic due to a variable number of tandem repeat (VNTR) region in the last exon. ... -
Characterization of NAA10 mutations in patients exhibiting phenotypes associated with N-terminal acetylation deficiency
(Master thesis, 2018-12-19)Approximately 80% of the proteins found in human cells are acetylated on their N-terminus, either partially or completely, by a group of enzymes called N-terminal acetyltransferases (NATs)^1. To date, seven NATs, NatA-NatF^2–7 ... -
Characterization of Not homeobox genes during development in Nematostella vectensis
(Master thesis, 2021-06-01) -
Characterization of regulatory T cells in Autoimmune Polyendocrine Syndrome type I, a model disease for autoimmunity
(Master thesis, 2018-12-21)The T and B lymphocytes of the adaptive immune system face the challenge of correctly recognizing antigens originating from a vast number of rapidly evolving pathogens, while ignoring those pertaining to the host itself. ... -
Characterization of the dopamine receptor genes in salmon louse, Lepeophtheirus Salmonis
(Master thesis, 2016-06-01) -
CRISPR/Cas9-mediated epigenetic repression of an enhancer linked to visceral obesity
(Master thesis, 2024-06-03)Projects like the Human Genome Project, ENCODE, and RoadMap Epigenomics have enabled genome-wide association studies (GWAS) to map associations between genetic variants and human disease. However, most variants detected ... -
Expression and function of the transcription factor Rx in Nematostella vectensis
(Master thesis, 2023-06-02)The development of the central nervous system is highly studied and a comparatively well understood field of neurogenesis. The fundamental aspects of neurogenesis have however mostly been studied in a select few bilaterian ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Identification of Epigenetic Modifications Following Treatment with Olanzapine
(Master thesis, 2018-12-19)No chronic disease burdens the world more than psychiatric disorders (Collins et al., 2011), with an estimated 40% of the population in 30 European countries affected in any given year (Insel et al., 2012). Current medical ...