Blar i Department of Chemistry på emneord "752299"
Viser treff 21-40 av 148
-
Characterizing Triacylglycerol in Cell Culture: Can LCMS replace HPTLC when assessing the effect of metformin in salmon in-vitro fatty liver model?
(Master thesis, 2017-10-25)Fatty liver, a health complication for aquacultured fish is developed by the deposition of triacylglycerol (TAG) within liver cells. Metformin has been proven to be an effective drug for ameliorating fatty liver in human ... -
Chemometric Approaches for the Validation and Optimization of a LC-MS/MS Method for the Analysis of Phenanthrene Metabolites in Atlantic Haddock Embryo
(Master thesis, 2023-04-27)The release of oil and petroleum products into the environment has long been a cause for concern due to its toxic effects on marine species. In particular, the Atlantic haddock has shown enhanced sensitivity towards the ... -
Chromatographic Fingerprinting and Quality Control of Herbal Medicines: Comparison of two officinal Chinese pharmacopoeia species of Dendrobii based on High-Performance Liquid Chromatography and Chemometric analysis
(Master thesis, 2013-08-29)The fingerprinting quantitative analysis combining similarity evaluation, Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) is a valid method for classification of herbal medicine ... -
Chromatographic Fingerprinting of Chinese Grape Berries
(Master thesis, 2014-04-14)Chromatographic fingerprints from three varieties of grapes produced in China (Giant Rose, Red Globe and Summer Black), were obtained by gas chromatography coupled with mass spectrometry. These grapes were subjected to ... -
Clathrate hydrate formation in different chemical environments relevant to subsurface CO2 storage
(Master thesis, 2018-09-12)Storing of carbon dioxide (CO2) as hydrates in the formation of the subsurface permafrost and oceanic areas around the world is a new method of carbon capture and storage (CCS). Clathrate hydrates are solids consisting of ... -
Cyclopentane Hydrate for Hydrate Wetting Studies
(Master thesis, 2013-06-03)Abstract Gas hydrates are often found in the systems for production of petroleum, natural gas and water systems, which is highly undesirable. In some systems the hydrates can form rapidly into large plugs and agglomerate ... -
Design and Synthesis of Carbazole Derivatives as Novel Therapeutic Candidates Against Acute Myeloid Leukaemia
(Master thesis, 2023-11-20)Akutt myelogen leukemi (AML) er ein heterogen gruppe blodkreft, karakterisert ved ukontrollert vekst av celler i den myelogene celle linja. Denne sjukdomsgruppa er assosiert med låg overlevingsrate, særleg hos eldre pasientar ... -
Design and Synthesis of Ruthenium based Olefin Metathesis Catalysts
(Master thesis, 2010-06-01)The present Master thesis seeks to develop new unsymmetrical ruthenium-based olefin metathesis catalysts and therein a better understanding of olefin metathesis catalysis with unsymmetrical active complexes. Such catalysts ... -
Design and Synthesis of xCT Inhibitor Candidates
(Master thesis, 2022-08-15) -
Design of iron(ii) spin-crossover compounds using de novo artificial evolution with fitness-function based on DommiMOE's implementation of LFMM
(Master thesis, 2015-06-01)This is a software development adding DommiMOE as a fitness-provider to the de novo artificial intelligence internally called Denoptim. The software supports stochastic conformational search, molecular dynamics, geometry ... -
"Det er vitenskapelig bevist at miljø er viktig" - En kvalitativ studie av hvordan ungdomsskoleelever bygger opp argumenter
(Master thesis, 2020-06-27)Argumentasjon og kritisk tenkning trekkes frem som to viktige begreper i den nye læreplanen. Dette er en av årsakene til at jeg i denne masteroppgaven har ønsket å studere hvordan elever bygger opp argumenter. Den overordnede ... -
Determining the Cell Size of Yeast Using Diffusion-Weighted NMR
(Master thesis, 2019-11-16)Abstract This study uses diffusion weighted NMR to determine yeast cell size at different times after those cells were suspended in water. Both the water diffusion and the metabolite diffusion where used in those measurements. ... -
Development and validation of a novel method for serotonin and 5-hydroxyindole-acetic acid determination in plasma using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-05-07)5-Hydroxytryptamine (5-HT) also known as serotonin is a biomarker in gastrointestinal disorder and several other pathological diseases where 5-HT and its metabolite 5-hydroxyindole-acetic acid are implicated. A sensitive ... -
Development of a novel extraction method for the analysis of prostaglandins and leukotrienes in fish liver by using liquid chromatography mass spectrometry
(Master thesis, 2015-09-06)Eicosanoids are the major metabolites of fatty acids and they have pro-inflammatory anti-inflammatory proprieties, their role and production in solid biological tissue is important due to correlation with many kinds of ... -
Development of a solid phase extraction method for evaluating the production of classic and nonclassic eicosanoids in human and fish cells using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-03-14)Eicosanoids are the major metabolites of fatty acids and they are correlated with many kinds of diseases such as Alzheimer's, cancer and cardiovascular diseases. Usually, most of the eicosanoids derived from omega-6 fatty ... -
Development of an extraction method for the analysis of pro-inflammatory prostaglandin-E2 and leukotriene-B4 in human plasma by liquid chromatography tandem mass spectrometry
(Master thesis, 2013-02-21)A simple and rapid method for extracting PGE2 and LTB4 from human plasma and further determination by LC-MS/MS proposed and validated. Extracting solvents, formic acid (10 µL) and acetonitrile (140 µL) were added subsequently ... -
Development of Methodology for the Synthesis of Cytotoxic NHC-Ag-Complexes
(Master thesis, 2016-06-02)Recently disclosed silver N-heterocyclic carbene complexes holding 4-alkylated imidazoles have been proved to hold cytotoxic properties. In this work, derivatives of such alkylated imidazoles were synthesised to be complexed ... -
Development of methods based on NIR and Raman spectroscopies together with chemometric tools for the qualitative and quantitative analysis of gasoline
(Master thesis, 2019-09-28)Gasoline quality control is essential for SI engines performance and to reduce environmental impacts by generation of undesirable pollutants. Methods established by the American Society for Test and Materials (ASTM) are ... -
Development of Small Molecules that Post-Transitionally Stabilizes the SMN Protein for the Treatment of Spinal Muscular Atrophy
(Master thesis, 2019-08-31)Spinal Muscular Atrophy is an autosomal recessive neurodegenerative disorder, caused by the lack of SMN genes. Previous work done by Laboratory for Drug Discovery in Neurodegeneration (LDDN) at Brigham and Women’s Hospital ... -
Direct Injection Electrospray Mass Spectrometry (DI-ESI-MS) and Liquid Chromatography Electrospray Mass Spectrometry (LC-ESI-MS) method development for characterisation of organic acids in petroleum and bio-oil samples
(Master thesis, 2017-05-09)Analysis and characterisation of complex mixtures such as petroleum and bio-oils are unarguably challenging. Finding suitable analytical method therefore needs to be considered carefully by analytical chemists. Electrospray ...