Browsing Department of Chemistry by Author "Jørgensen, Kåre Bredeli"

Now showing items 1-3 of 3

    • Alkyl-phenanthrenes in early life stage fish: differential toxicity in Atlantic haddock (Melanogrammus aeglefinus) embryos 

      Donald, Carey; Nakken, Charlotte L.; Sørhus, Elin; Perrichon, Prescilla; Jørgensen, Kåre Bredeli; Bjelland, Hege K.; Stølen, Christine; Kancherla, Sindhu; Mayer, Philipp; Meier, Sonnich (Journal article; Peer reviewed, 2023)
      Tricyclic polycyclic aromatic hydrocarbons (PAHs) are believed to be the primary toxic components of crude oil. Such compounds including phenanthrene are known to have direct effects on cardiac tissue, which lead to ...

    • Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae 

      Donald, Carey; Sørhus, Elin; Perrichon, Prescilla; Nakken, Charlotte L.; Goksøyr, Anders; Jørgensen, Kåre Bredeli; Mayer, Philipp; da Silva, Denis A.M.; Meier, Sonnich (Journal article; Peer reviewed, 2023)
      Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing crude oil toxicity because of similar morphological defects in fish. However, PAH concentrations are often not high enough to explain the ...

    • Kinase chemodiversity from the Arctic: the breitfussins 

      Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Peer reviewed; Journal article, 2019)
      In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ...