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dc.contributor.authorWyller, Vegard B.
dc.contributor.authorEriksen, Hege Randi
dc.contributor.authorMalterud, Kirsti
dc.date.accessioned2015-01-20T13:51:33Z
dc.date.available2015-01-20T13:51:33Z
dc.date.issued2009-02-23eng
dc.identifier.issn1744-9081
dc.identifier.urihttps://hdl.handle.net/1956/9221
dc.description.abstractWe present an integrative model of disease mechanisms in the Chronic Fatigue Syndrome (CFS), unifying empirical findings from different research traditions. Based upon the Cognitive activation theory of stress (CATS), we argue that new data on cardiovascular and thermoregulatory regulation indicate a state of permanent arousal responses – sustained arousal – in this condition. We suggest that sustained arousal can originate from different precipitating factors (infections, psychosocial challenges) interacting with predisposing factors (genetic traits, personality) and learned expectancies (classical and operant conditioning). Furthermore, sustained arousal may explain documented alterations by establishing vicious circles within immunology (Th2 (humoral) vs Th1 (cellular) predominance), endocrinology (attenuated HPA axis), skeletal muscle function (attenuated cortical activation, increased oxidative stress) and cognition (impaired memory and information processing). Finally, we propose a causal link between sustained arousal and the experience of fatigue. The model of sustained arousal embraces all main findings concerning CFS disease mechanisms within one theoretical framework.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0eng
dc.titleCan sustained arousal explain the Chronic Fatigue Syndrome?eng
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2013-08-28T16:57:51Z
dc.description.versionpublishedVersion
dc.description.versionPeer Reviewed
dc.rights.holderCopyright 2009 Wyller et al; licensee BioMed Central Ltd.
dc.rights.holderVegard B Wyller et al.; licensee BioMed Central Ltd.eng
dc.source.articlenumber10
dc.identifier.doihttps://doi.org/10.1186/1744-9081-5-10
dc.identifier.cristin501025
dc.source.journalBehavioral and Brain Functions
dc.source.405


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