Browsing Faculty of Medicine by Journals "BMC Cancer"
Now showing items 21-31 of 31
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Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide
(Peer reviewed; Journal article, 2011-12-20)Background: Expression of neuronal elements has been identified in various glial tumors, and glioblastomas (GBMs) with neuronal differentiation patterns have reportedly been associated with longer survival. However, the ... -
Oxidative stress in susceptibility to breast cancer: study in Spanish population
(Peer reviewed; Journal article, 2014-11-21)Background: Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort : a case control study
(Peer reviewed; Journal article, 2006-03-16)Background: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
Predictors of adherence and the role of primary non-adherence in antihormonal treatment of breast cancer
(Journal article; Peer reviewed, 2022-12-02)Background: Antihormonal treatment for hormone receptor (HR) positive breast cancer has highly beneficial effects on both recurrence rates and survival. We investigate adherence and persistence in this group of ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Peer reviewed; Journal article, 2012-01-25)Background: Today’s clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced ... -
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
(Peer reviewed; Journal article, 2013-10-05)Background: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation ... -
A reproducible brain tumour model established from human glioblastoma biopsies
(Peer reviewed; Journal article, 2009-12-29)Background: Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient ... -
Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer
(Peer reviewed; Journal article, 2012-06-15)Background: Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling ... -
Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors
(Peer reviewed; Journal article, 2019-03-15)Background: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the ... -
Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas
(Peer reviewed; Journal article, 2008-12-05)Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ... -
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
(Peer reviewed; Journal article, 2017-02-07)Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ...