Blar i Faculty of Medicine på emneord "Prognosis"
Viser treff 1-20 av 27
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Addition of eGFR and age improves the prognostic absolute renal risk-model in 1,134 norwegian patients with IgA nephropathy
(Peer reviewed; Journal article, 2015-05)Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the ... -
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival
(Peer reviewed; Journal article, 2017)Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ... -
Characterization of FGD5 expression in primary breast cancers and lymph node metastases
(Peer reviewed; Journal article, 2018)Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ... -
Comparing withdrawal and non-withdrawal of life-sustaining treatment among patients who died from stroke
(Peer reviewed; Journal article, 2015)Background: In severe stroke, a decision to withdraw life-sustaining treatment is sometimes made in cooperation with the family. The aim of this study was to study the time from withdrawing life-sustaining treatment to ... -
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients
(Peer reviewed; Journal article, 2019-05-09)Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the ... -
Cumulative prognostic score predicting mortality in patients older than 80 years admitted to the ICU
(Peer reviewed; Journal article, 2019-06)OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of ... -
DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer
(Peer reviewed; Journal article, 2015-04-21)Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ... -
FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis
(Peer reviewed; Journal article, 2017-04)Purpose: Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ... -
Global left ventricular load in asymptomatic aortic stenosis: covariates and prognostic implication (the SEAS trial)
(Peer reviewed; Journal article, 2012-11-05)Introduction: Valvuloarterial impedance (Zva) is a measure of global (combined valvular and arterial) load opposing left ventricular (LV) ejection in aortic stenosis (AS). The present study identified covariates and tested ... -
Hepatoid adenocarcinoma of the stomach - Proper identification and treatment remain a challenge
(Peer reviewed; Journal article, 2016)Objective: The term hepatoid adenocarcinoma (HAC) of the stomach was introduced three decades ago with the observation of high serum α-fetoprotein (AFP) levels in some gastric adenocarcinoma patients. This very rare gastric ... -
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer
(Peer reviewed; Journal article, 2011)Background: Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m−2) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological ... -
High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function
(Peer reviewed; Journal article, 2017)Purpose: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer ... -
Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial
(Peer reviewed; Journal article, 2013-11)Background: Preoperative histologic examination of tumour tissue is essential when deciding if endometrial cancer surgery should include lymph node sampling. We wanted to investigate if biomarkers could improve prediction ... -
IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age
(Peer reviewed; Journal article, 2015-07)Follicular lymphoma (FL) is a heterogeneous disease with some patients developing progressively or transformed disease early, whereas others follow an indolent clinical course. We evaluated the prognostic value of ... -
Improved prognosis in Norwegian patients with glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies
(Peer reviewed; Journal article, 2014-02-17)Background. Glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased mortality and a high risk of end-stage renal disease (ESRD). Here, we investigated whether the ... -
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
(Peer reviewed; Journal article, 2012)BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ... -
A multicenter study on Leigh syndrome: disease course and predictors of survival
(Peer reviewed; Journal article, 2014-04-15)Background: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite the fact that Leigh syndrome is the most ... -
Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours
(Peer reviewed; Journal article, 2014-01)Natural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in ... -
A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation
(Peer reviewed; Journal article, 2018-10-31)Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients ... -
Predicting outcomes in patients with perforated gastroduodenal ulcers: artificial neural network modelling indicates a highly complex disease
(Peer reviewed; Journal article, 2014-06-14)Purpose Mortality prediction models for patients with perforated peptic ulcer (PPU) have not yielded consistent or highly accurate results. Given the complex nature of this disease, which has many non-linear associations ...