Browsing Faculty of Medicine by Author "Fredly, Hanne Kristin"
Now showing items 1-4 of 4
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
Fredly, Hanne Kristin; Ersvær, Elisabeth; Kittang, Astrid Marta Olsnes; Tsykunova, Galina; Gjertsen, Bjørn Tore; Bruserud, Øystein (Peer reviewed; Journal article, 2013-08-01)Background: A large proportion of patients with acute myeloid leukemia (AML) are not fit for intensive and potentially curative therapy due to advanced age or comorbidity. Previous studies have demonstrated that a subset ... -
Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents
Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Bruserud, Øystein (Peer reviewed; Journal article, 2013-07-30)Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode S.; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2019-10-10)Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment. The ...