• Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci 

      Hajdarevic, Riad; Lande, Asgeir; Rekeland, Ingrid Gurvin; Rydland, Anne; Strand, Elin B.; Sosa, Daysi Duarte; Creary, Lisa E; Mella, Olav; Egeland, Torstein; Saugstad, Ola Didrik; Fluge, Øystein; Lie, Benedicte Alexandra; Viken, Marte Kathrine (Journal article; Peer reviewed, 2021)
      The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but involvement of the immune system is one of the proposed underlying mechanisms. Human leukocyte antigen (HLA) associations are ...
    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...
    • The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts 

      Hou, Ruihua; Ye, Gang; Cheng, Xiaojing; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlen, Barbro; Dahlen, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Auffray, Charles; De Meulder, Bertrand; Sousa, Ana R.; Adcock, Ian M.; Fan Chung, Kian; Sterk, Peter J.; Skipp, Paul J.; Schofield, James; Djukanović, Ratko (Journal article; Peer reviewed, 2023)
      Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the ...
    • Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia 

      Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan; Szabo, Attila (Journal article; Peer reviewed, 2021)
      Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ...