Blar i Faculty of Medicine på tidsskrift "British Journal of Cancer"

Viser treff 1-20 av 24

    • A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease 

      Halle, Mari Kyllesø; Sødal, Marte; Forsse, David Erik; Engerud, Hilde Renate; Woie, Kathrine; Lura, Njål Gjærde; Wagner-Larsen, Kari Strøno; Trovik, Jone; Bertelsen, Bjørn; Haldorsen, Ingfrid S.; Ojesina, Akinyemi I.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Background: Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated ...

    • Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts 

      Fritz, Josef; Jochems, Sylvia H. J.; Bjørge, Tone; Wood, Angela M.; Häggström, Christel; Ulmer, Hanno; Nagel, Gabriele; Zitt, Emanuel; Engeland, Anders; Harlid, Sophia; Drake, Isabel; Stattin, Pär; Stocks, Tanja (Journal article; Peer reviewed, 2024)
      Background Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited. Methods We included 259,884 men from eight European ...

    • Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival 

      Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-08-15)
      Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ...

    • Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma 

      Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Høivik, Erling Andre; Westin, Shannon; Trovik, Jone; Haldorsen, Ingfrid S.; Mills, Gordon B.; Krakstad, Camilla; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2020-02-10)
      Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ...

    • Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer 

      Meltzer, Sebastian; Negård, Anne; Bakke, Kine Mari; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Flatmark, Kjersti; Ree, Anne Hansen (Journal article; Peer reviewed, 2022)
      Background: Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility. Methods: Previously untreated, ...

    • Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers 

      Shala, Nita Kaupang; Stenehjem, Jo; Babigumira, Ronnie; Liu, Fei-Chih; Berge, Leon Alexander Mclaren; Silverman, Debra T.; Friesen, Melissa C.; Rothman, Nathaniel; Lan, Qing; Hosgood, H. Dean; Samuelsen, Sven Ove; Bråtveit, Magne; Kirkeleit, Jorunn; Andreassen, Bettina Kulle; Veierød, Marit Bragelien; Grimsrud, Tom Kristian (Journal article; Peer reviewed, 2023)
      Background Occupational exposures constitute the second leading cause of urinary bladder cancer after tobacco smoking. Increased risks have been found in the petroleum industry, but high-quality exposure data are needed ...

    • Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients 

      Tangen, Ingvild Løberg; Kopperud, Reidun Kristin; Visser, Nicole C.M.; Staff, Anne Cathrine; Tingulstad, Solveig; Marcickiewicz, Janusz; Amant, Frédéric; Bjørge, Line; Pijnenborg, Johanna M.A.; Salvesen, Helga; Werner, Henrica Maria Johanna; Trovik, Jone; Krakstad, Camilla (Peer reviewed; Journal article, 2017-09)
      Background: Several studies have identified L1 cell adhesion molecule (L1CAM) as a strong prognostic marker in endometrial cancer. To further underline the clinical usefulness of this biomarker, we investigated L1CAM as a ...

    • HER2 expression patterns in paired primary and metastatic endometrial cancer lesions 

      Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Berg, Hege Fredriksen; Hoivik, Erling A; Mauland, Karen Klepsland; Kusonmano, Kanthida; Berg, Anna; Hurtado, Antoni; Kalland, Karl-Henning; Øyan, Anne Margrete; Stefansson, Ingunn; Vintermyr, Olav Karsten; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2017-11-23)
      Background: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers ...

    • High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer 

      Mauland, Karen Klepsland; Trovik, Jone; Wik, Elisabeth; Ræder, Maria B.; Njølstad, Tormund Salvesen; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjørge, Tone; Akslen, Lars A.; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2011)
      Background: Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m−2) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological ...

    • HPV self-sampling among long-term non-attenders to cervical cancer screening in Norway: a pragmatic randomised controlled trial 

      Aasbø, Gunvor; Trope, Ameli; Nygård, Mari; Christiansen, Irene Kraus; Baasland, Ingrid; Iversen, Grete Alræk; Munk, Ane Cecilie Dæhli; Christiansen, Marit Halonen; Presthus, Gro Kummeneje; Undem, Karina; Bjørge, Tone; Castle, Philip E.; Hansen, Bo Lars Thorvald Terning (Journal article; Peer reviewed, 2022)
      Background Cervical cancer screening participation is suboptimal in most settings. We assessed whether human papillomavirus (HPV) self-sampling may increase screening participation among long-term non-attenders in Norway. ...

    • Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients 

      Larsen, Stein Gunnar; Goscinski, Mariusz Adam; Dueland, Svein; Steigen, Sonja Eriksson; Hofsli, Eva; Torgunrud, A.; Lund-Iversen, Marius; Dagenborg, Vegar Johansen; Flatmark, Kjersti; Sorbye, Halfdan (Journal article; Peer reviewed, 2021)
      Background Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal ...

    • Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas 

      Haldorsen, Ingfrid S.; Stefansson, Ingunn; Grüner, Renate; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Taxt, Torfinn; Akslen, Lars A.; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014)
      Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance ...

    • KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer 

      Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012)
      BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ...

    • Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value 

      Berg, Hege Fredriksen; Engerud, Hilde Renate; Myrvold, Madeleine; Lien, Hilde Eide; Hjelmeland, Marta Espevold; Halle, Mari Kyllesø; Woie, Kathrine; Høivik, Erling Andre; Haldorsen, Ingfrid S.; Vintermyr, Olav Karsten; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2022)
      Background The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples and investigate the prognostic ...

    • A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer 

      Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2022)
      Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ...

    • Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Morken, Siren; Langer, Seppo W.; Sundlöv, Anna; Vestermark, Lene Weber; Ladekarl, Morten; Hjortland, Geir Olav; Svensson, Johanna B.; Tabaksblat, Elizaveta Mitkina; Haslerud, Torjan Magne; Assmus, Jörg; Detlefsen, Sönke; Couvelard, Anne; Perren, Aurel; Sorbye, Halfdan (Journal article; Peer reviewed, 2023)
      Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ...

    • Poor outcome in hypoxic endometrial carcinoma is related to vascular density 

      Reijnen, Casper; van Weelden, Willem Jan; Arts, Martijn S.J.P.; Peters, Johan P.; Rijken, Paul F.; van de Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Reques, Armando; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Minar, Lubos; Jandakova, Eva; Snijders, Marc P.L.M.; van den Berg-van Erp, Saskia; Küsters-Vandevelde, Heidi V.N.; Matias-Guiu, Xavier; Amant, Frederic; Massuger, Leon F.A.G.; Bussink, Johan; Pijnenborg, Johanna M.A. (Peer reviewed; Journal article, 2019-04-23)
      Background Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Methods Tumour slides ...

    • Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based study 

      Sköld, Camilla; Bjørge, Tone; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Grotmol, Tom; Madanat-Harjuoja, Laura-Maria; Ording, Anne Gulbech; Trabert, Britton; Tretli, Steinar; Troisi, Rebecca; Sørensen, Henrik Toft; Glimelius, Ingrid (Journal article; Peer reviewed, 2020)
      Background Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, ...

    • Prevalence and implications of elevated microsatellite alterations at selected tetranucleotides in cancer 

      Watson, Martin M; Berg, Marianne; Søreide, Kjetil (Peer reviewed; Journal article, 2014-04-01)
      Elevated microsatellite alterations at selected tetranucleotides (EMAST), a variation of microsatellite instability (MSI), has been reported in a variety of malignancies (e.g., neoplasias of the lung, head and neck, ...

    • Real-world data on cervical cancer risk stratification by cytology and HPV genotype to inform the management of HPV-positive women in routine cervical screening 

      Hashim, Dana; Engesæter, Birgit Øvstebø; Skare, Gry Baadstrand; Castle, Philip E.; Bjørge, Tone; Trope, Ameli; Nygård, Mari (Journal article; Peer reviewed, 2020)
      Background HPV16/18 detection may improve cervical cancer risk stratification and better guide which HPV-positive women warrant immediate colposcopy/biopsy. We estimated risks of cervical precancer and cancer by HPV ...