Browsing Faculty of Medicine by Journals "Nature Communications"
Now showing items 41-55 of 55
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Patterns of genomic evolution in advanced melanoma
(Peer reviewed; Journal article, 2018-07-10)Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ... -
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
(Journal article; Peer reviewed, 2021)Host-directed-therapy strategies are warranted to fight tuberculosis. Here we assess the safety and immunogenicity of adjunctive vaccination with the H56:IC31 candidate and cyclooxygenase-2-inhibitor treatment (etoricoxib) ... -
Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa
(Journal article; Peer reviewed, 2023)Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) with ... -
A proteomics sample metadata representation for multiomics integration and big data analysis
(Journal article; Peer reviewed, 2021)The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ... -
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
(Journal article; Peer reviewed, 2022)The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ... -
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
(Journal article; Peer reviewed, 2020)The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part ... -
Sex differences in oncogenic mutational processes
(Journal article; Peer reviewed, 2020)Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ... -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
(Journal article; Peer reviewed, 2021)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ... -
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
(Journal article; Peer reviewed, 2021)Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and ... -
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
(Peer reviewed; Journal article, 2019-04-16)The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma ... -
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
(Journal article; Peer reviewed, 2022)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and ... -
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
(Peer reviewed; Journal article, 2018)General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank ... -
Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries
(Journal article; Peer reviewed, 2023)Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We ... -
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
(Peer reviewed; Journal article, 2019-09-02)The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ... -
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
(Journal article; Peer reviewed, 2022)Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome ...