Blar i Faculty of Medicine på forfatter "Bramham, Clive R."
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Arc interacts with the integral endoplasmic reticulum protein, calnexin
Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Nair Raveendran, Rajeevkumar; Bramham, Clive R. (Peer reviewed; Journal article, 2017-09-20)Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ... -
Arc is a flexible modular protein capable of reversible self-oligomerization
Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
The Arc of synaptic memory
Bramham, Clive R.; Alme, Maria N.; Bittins, Margarethe; Kuipers, Sjoukje D.; Nair, Rajeevkumar R.; Pai, Balagopal; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin (Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis
Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. (Peer reviewed; Journal article, 2016-02-18)Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ... -
Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders
Zhang, Hongyu; Bramham, Clive R. (Journal article; Peer reviewed, 2020-07-10)AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ... -
Common variants in the ARC gene are not associated with cognitive abilities
Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Peer reviewed; Journal article, 2015-09-03)Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ... -
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive R.; Timmusk, Tõnis (Peer reviewed; Journal article, 2020)BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ... -
DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
Håvik, Bjarte; Fernandes, Carla P. D.; Christoforou, Andrea; Ersland, Kari Merete; Giddaluru, Sudheer; Cichon, Sven; Steen, Vidar Martin; Hellard, Stéphanie Le; Johansson, Stefan; Bramham, Clive R.; Haavik, Jan (Peer reviewed; Journal article, 2012-04-23)Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. ... -
Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo
Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R. (Peer reviewed; Journal article, 2017-05-10)Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ... -
Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity
Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin (Peer reviewed; Journal article, 2015-10-01)Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the ... -
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
Wibrand, Karin; Berge, Kjetil; Messaoudi, Michaël; Duffaud, Anaïs; Panja, Debabrata; Bramham, Clive R.; Burri, Lena (Peer reviewed; Journal article, 2013-01-25)Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). ... -
GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek (Peer reviewed; Journal article, 2017-06-16)The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ... -
Implication of the APP gene in intellectual abilities
Myrum, Craig; Nikolaienko, Oleksii; Bramham, Clive R.; Haavik, Jan; Zayats, Tetyana (Peer reviewed; Journal article, 2017)Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the ... -
MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc
Wibrand, Karin; Pai, Balagopal; Siripornmongcolchai, Taweeporn; Bittins, Margarethe; Berentsen, Birgitte; Ofte, May Lillian; Weigel, Arwed; Skaftnesmo, Kai Ove; Bramham, Clive R. (Peer reviewed; Journal article, 2012-07-26)Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific ... -
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo
Pai, Balagopal; Siripornmongcolchai, Taweeporn; Berentsen, Birgitte; Pakzad, Ashraf; Vieuille, Christel Marie; Pallesen, Ståle; Pajak, Maciej; Simpson, T. Ian; Armstrong, J. Douglas; Wibrand, Karin; Bramham, Clive R. (Peer reviewed; Journal article, 2014-01-13)microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ... -
Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis
Schubert, Manja; Panja, Debabrata; Haugen, Mette; Bramham, Clive R.; Vedeler, Christian A. (Peer reviewed; Journal article, 2014-12)Paraneoplastic cerebellar degeneration (PCD) is characterized by loss of Purkinje cells (PCs) associated with progressive pancerebellar dysfunction in the presence of onconeural Yo antibodies. These antibodies recognize ... -
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons
Leal, Graciano; Comprido, Diogo; de Luca, Pasqualino; Morais, Eduardo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; Costa, Rui O.; Pinto, Maria Joana; Patil, Sudarshan; Berentsen, Birgitte; Afonso, Pedro; Carreto, Laura; Li, Ka Wan; Pinheiro, Paulo; Almeida, Ramiro D.; Santos, Manuel A. S.; Bramham, Clive R.; Duarte, Carlos B. (Peer reviewed; Journal article, 2017-11)Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the ... -
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons
Ishizuka, Yuta; Bramham, Clive R. (Peer reviewed; Journal article, 2019-03)Background Primary neuronal cultures are widely used to elucidate fundamental aspects of neuronal anatomy, physiology, cell biology, and neuronal dysfunction in animal models of disease. However, preparation of primary ... -
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
Grønli, Janne; Soule, Jonathan; Bramham, Clive R. (Peer reviewed; Journal article, 2014-01-21)Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic ... -
Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy
Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne (Peer reviewed; Journal article, 2016-01)Background and aims: Peripheral neuropathic pain is described as a pain state caused by an injury or dysfunction of the nervous system, and could have clinical manifestations such as hyperalgesia, allodynia and spontaneous ...