Browsing Faculty of Medicine by Author "Gaare, Johannes"

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    • Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology 

      SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Ying Q.; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo; Achanta, Kavya; Kassahun, Henok; Stavgiannoudaki, Ioanna; Bohr, Vilhelm A.; Akbari, Mansour; Gaare, Johannes; Tzoulis, Charalampos; Tavernarakis, Nektarios; Nilsen, Hilde (Journal article; Peer reviewed, 2021)
      Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, ...