Browsing Faculty of Medicine by Journals "BMC Bioinformatics"

Now showing items 1-6 of 6

    • Detecting diferentially methylated regions using a fast wavelet‑based approach to functional association analysis 

      Denault, William Robert Paul; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background We present here a computational shortcut to improve a powerful wavelet-based method by Shim and Stephens (Ann Appl Stat 9(2):665–686, 2015. https://doi.org/10.1214/14-AOAS776) called WaveQTL that was originally ...

    • Gel2DE - A software tool for correlation analysis of 2D gel electrophoresis data 

      Øye, Ola Kristoffer; Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Sulen, André; Ulvang, Dag Magne; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-06)
      Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique for studying protein isoforms and their modifications. Existing commercial 2D image analysis tools rely on spot detection that limits analysis ...

    • Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls 

      Gjerdevik, Miriam; Jugessur, Astanand; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Cordell, Heather J.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2019-04-02)
      Background: Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent ...

    • Integrating protein structural dynamics and evolutionary analysis with Bio3D 

      Skjærven, Lars; Yao, Xin-Qiu; Scarabelli, Guido; Grant, Barry J. (Peer reviewed; Journal article, 2014-12-10)
      Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining how ...

    • Prediction of indirect interactions in proteins 

      Prusis, Peteris; Uhlén, Staffan; Petrovska, Ramona; Lapinsh, Maris; Wikberg, Jarl E. S. (Peer reviewed; Journal article, 2006-03-22)
      Background: Both direct and indirect interactions determine molecular recognition of ligands by proteins. Indirect interactions can be defined as effects on recognition controlled from distant sites in the proteins, e.g. ...

    • Wavelet Screening: a novel approach to analyzing GWAS data 

      Denault, William Robert Paul; Gjessing, Håkon K.; Juodakis, Julius; Jacobsson, Bo; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background Traditional methods for single-variant genome-wide association study (GWAS) incur a substantial multiple-testing burden because of the need to test for associations with a vast number of single-nucleotide ...