Browsing Faculty of Medicine by Journals "BMC Cancer"
Now showing items 1-20 of 31
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Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
(Peer reviewed; Journal article, 2017-05-19)Background: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously ... -
Clinical decision making in cancer care: a review of current and future roles of patient age
(Peer reviewed; Journal article, 2018-05-09)Background: Patient age is among the most controversial patient characteristics in clinical decision making. In personalized cancer medicine it is important to understand how individual characteristics do affect practice ... -
Design of the study: How can health care help female breast cancer patients reduce their stress symptoms? A randomized intervention study with stepped-care
(Peer reviewed; Journal article, 2012-05-04)Background: A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the ... -
Early rehabilitation of cancer patients - a randomized controlled intervention study
(Peer reviewed; Journal article, 2013-01-07)Background: Faced with a life-threatening illness, such as cancer, many patients develop stress symptoms, i.e. avoidance behaviour, intrusive thoughts and worry. Stress management interventions have proven to be effective; ... -
The effect of low-level laser irradiation (Ga-Al-AsP - 660nm) on in vitro and in vivo melanoma
(Peer reviewed; Journal article, 2009-11-20)Background It has been speculated that the biostimulatory effect of Low Level Laser Therapy could cause undesirable enhancement of tumor growth in neoplastic diseases. The aim of the present study is to analyze the behavior ... -
Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
(Peer reviewed; Journal article, 2012-10-05)Background: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the ... -
Exploring uncertainty and use of real-world data in the National Institute for Health and Care Excellence single technology appraisals of targeted cancer therapy
(Journal article; Peer reviewed, 2022)Objectives Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technology. ... -
Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen
(Peer reviewed; Journal article, 2013-07-11)Background: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline ... -
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
(Peer reviewed; Journal article, 2012-01-17)Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ... -
Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia
(Peer reviewed; Journal article, 2009-03-05)Background: The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect ... -
Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: A retrospective study
(Peer reviewed; Journal article, 2019-06-07)Background Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and involves alterations in insulin metabolism, response to ... -
Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes
(Peer reviewed; Journal article, 2018-06-15)Background High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of ... -
Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review
(Journal article; Peer reviewed, 2023)Purpose Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies. However, the detrimental side effects of treatment make it difficult for ... -
Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients - a randomized trial
(Peer reviewed; Journal article, 2019-11-08)Background: Conflicting results have been reported on the influence of carbohydrates in breast cancer. Objective: To determine the influence of pre-operative per-oral carbohydrate load on proliferation in breast tumors. ... -
Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinoma
(Peer reviewed; Journal article, 2009-12-08)Background: Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected ... -
Lipocalin 2 expression is associated with aggressive features of endometrial cancer
(Peer reviewed; Journal article, 2012-05-06)Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ... -
MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
(Peer reviewed; Journal article, 2017-02-03)Background: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
(Peer reviewed; Journal article, 2019-12-04)Background: The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project
(Peer reviewed; Journal article, 2014-02-18)Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related ... -
Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma
(Peer reviewed; Journal article, 2019-01-05)Background Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ...