Browsing Faculty of Medicine by Journals "BMC Genomics"
Now showing items 1-15 of 15
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Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
(Journal article; Peer reviewed, 2020)Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ... -
Comprehensive characterization of copy number variation (CNV) called from array, long- and short-read data
(Journal article; Peer reviewed, 2021)Background SNP arrays, short- and long-read genome sequencing are genome-wide high-throughput technologies that may be used to assay copy number variants (CNVs) in a personal genome. Each of these technologies comes with ... -
Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development
(Peer reviewed; Journal article, 2012-01-10)Background: MicroRNAs (miRNAs) play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. ... -
Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography
(Journal article; Peer reviewed, 2022)Background: We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial ... -
Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4
(Journal article; Peer reviewed, 2021)Background Studies on the airway microbiome have been performed using a wide range of laboratory protocols for high-throughput sequencing of the bacterial 16S ribosomal RNA (16S rRNA) gene. We sought to determine the ... -
A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population
(Journal article; Peer reviewed, 2021)Background Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since ... -
Gene expression profiles in rat brain disclose CNS signature genes and regional patterns of functional specialisation
(Peer reviewed; Journal article, 2007-04-04)Background: The mammalian brain is divided into distinct regions with structural and neurophysiological differences. As a result, gene expression is likely to vary between regions in relation to their cellular composition ... -
Genome wide response to dietary tetradecylthioacetic acid supplementation in the heart of Atlantic Salmon (Salmo salar L.)
(Peer reviewed; Journal article, 2012-05-11)Background: Under-dimensioned hearts causing functional problems are associated with higher mortality rates in intensive Atlantic salmon aquaculture. Previous studies have indicated that tetradecylthioacetic acid (TTA) ... -
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells
(Peer reviewed; Journal article, 2010-11-25)Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA ... -
High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example
(Peer reviewed; Journal article, 2008-07-02)Background: While the genomic annotations of diverse lineages of the Mycobacterium tuberculosis complex are available, divergences between gene prediction methods are still a challenge for unbiased protein dataset generation. ... -
MicroRNAs enrichment in GWAS of complex human phenotypes
(Peer reviewed; Journal article, 2015-04-16)Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ... -
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
(Journal article; Peer reviewed, 2022)Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
(Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
(Journal article; Peer reviewed, 2021)Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells ... -
Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.
(Peer reviewed; Journal article, 2017-03-23)Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ...