Blar i Faculty of Medicine på tidsskrift "Frontiers in Oncology"

Viser treff 1-19 av 19

    • Brainstem NTCP and dose constraints for carbon ion RT—Application and translation from Japanese to European RBE-weighted dose 

      Dale, Jon Espen; Molinelli, Silvia; Vischioni, Barbara; Vitolo, Viviana; Bonora, Maria; Magro, Giuseppe; Mairani, Andrea; Hasegawa, Azusa; Ohno, Tatsuya; Dahl, Olav; Valvo, Francesca; Fossati, Piero (Journal article; Peer reviewed, 2020)
      Background and Purpose: The Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS). However, ...

    • Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study 

      Kjellstadli, Camilla; Forster, Rachel Bedenis; Myklebust, Tor Åge; Bjørge, Tone; Bønaa, Kaare Harald; Helle, Svein Inge; Kvåle, Rune (Journal article; Peer reviewed, 2023-03-31)
      Objective: To investigate differences in cardiovascular disease (CVD) morbidity and mortality after radical prostatectomy or definitive radiotherapy with or without androgen deprivation therapy (ADT). Materials and ...

    • CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup 

      Aasebø, Kristine; Dragomir, Anca; Sundström, Magnus; Mezheyeuski, Artur; Edqvist, Per-Henrik; Eide, Geir Egil; Pontén, Fredrik; Pfeiffer, Per; Glimelius, Bengt; Sorbye, Halfdan (Journal article; Peer reviewed, 2020-02-11)
      Background: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type ...

    • Colony stimulating factor 1 receptor in acute myeloid leukemia 

      Sletta, Kristine Yttersian; Marin, Oriol Castells; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)
      Acute myeloid leukemia (AML) is an aggressive heterogeneous blood cancer derived from hematopoietic stem cells. Tumor-stromal interactions in AML are of importance for disease development and therapy resistance, and bone ...

    • Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy 

      Klein, Eliane; Hau, Ann-Christin; Oudin, Anaïs; Golebiewska, Anna; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-12-08)
      Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall survival is roughly over a year. New therapeutic ...

    • Global inequities in precision medicine and molecular cancer research 

      Drake, Thomas M.; Knight, Stephen R.; Harrison, Ewen M.; Søreide, Kjetil (Peer reviewed; Journal article, 2018-09-04)
      Precision medicine based upon molecular testing is heralded as a revolution in how cancer is prevented, diagnosed, and treated. Large efforts across the world aim to conduct comprehensive molecular profiling of disease to ...

    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...

    • The Interplay Between Prostate Cancer Genomics, Metabolism, and the Epigenome: Perspectives and Future Prospects 

      Singh, Reema; Mills, Ian (Journal article; Peer reviewed, 2021)
      Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the ...

    • Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models 

      Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James; Dyrstad, Sissel Elisabeth; Ekanger, Camilla Tvedt; Lu, Ning; Frantz, Kirstine; Stuhr, Linda Elin Birkhaug; Ditzel, Henrik J.; Thiery, Jean Paul; Akslen, Lars Andreas; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2022)
      The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional ...

    • KRAS-G12C mutation in one real-life and three population-based Nordic cohorts of metastatic colorectal cancer 

      Osterlund, Emerik; Ristimäki, Ari; Kytölä, Soili; Kuopio, Teijo; Heervä, Eetu; Muhonen, Timo; Halonen, Päivi; Kallio, Raija; Soveri, Leena-Maija; Sundström, Jari; Keinänen, Mauri; Ålgars, Annika; Ristamäki, Raija; Sorbye, Halfdan; Pfeiffer, Per; Nunes, Luís; Salminen, Tapio; Lamminmäki, Annamarja; Mäkinen, Markus J.; Sjöblom, Tobias; Isoniemi, Helena; Glimelius, Bengt; Osterlund, Pia (Journal article; Peer reviewed, 2022-02-16)
      Background: KRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been ...

    • LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

      Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)
      Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...

    • MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells 

      Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)
      Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ...

    • The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma 

      Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019-09-27)
      Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ...

    • Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022 

      Robijns, Jolien; Nair, Raj G.; Lodewijckx, Joy; Arany, Praveen; Barasch, Andrei; Bjordal, Jan Magnus; Bossi, Paolo; Chilles, Anne; Corby, Patricia M.; Epstein, Joel B.; Elad, Sharon; Fekrazad, Reza; Fregnani, Eduardo Rodrigues; Genot, Marie-Thérèse; Ibarra, Ana M. C.; Hamblin, Michael R.; Heiskanen, Vladimir; Hu, Ken; Klastersky, Jean; Lalla, Rajesh; Latifian, Sofia; Maiya, Arun; Mebis, Jeroen; Migliorati, Cesar A.; Milstein, Dan M. J.; Murphy, Barbara; Raber-Durlacher, Judith E.; Roseboom, Hendrik J.; Sonis, Stephen; Treister, Nathaniel; Zadik, Yehuda; Bensadoun, René-Jean (Journal article; Peer reviewed, 2022)
      Disclaimer: This article is based on recommendations from the 12th WALT Congress, Nice, October 3-6, 2018, and a follow-up review of the existing data and the clinical observations of an international multidisciplinary ...

    • PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas 

      Ohba, Shigeo; Tang, Yongjian; Johannessen, Tor-Christian Aase; Mukherjee, Joydeep (Journal article; Peer reviewed, 2022)
      PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ...

    • Stage-dependent prognostic shift in mismatch repair-deficient tumors: Assessing patient outcomes in stage II and III colon cancer 

      Hestetun, Kjersti Elvestad; Rosenlund, Nina Benedikte; Stanisavljevic, Luka; Dahl, Olav; Myklebust, Mette Pernille (Journal article; Peer reviewed, 2022)
      Introduction: Deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H) is associated with an improved prognosis in colon cancer stage II but poor prognosis in stage IV colon cancer. The clinical significance ...

    • The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis 

      Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo; Nilsen, Mette Hartmark; Otragane, Sarah-Muheha Anni; Heggdal, Jan Ingemann; Selheim, Frode; Ceña, Valentín; Bjørsvik, Hans-René; Enger, Per Øyvind (Journal article; Peer reviewed, 2022)
      Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ...

    • Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters 

      Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)
      Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ...

    • Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis 

      Martínez-Nieto, Guillermo A.; Teppo, Hanna-Riikka; Petrelius, Noora; Izzi, Valerio; Devarajan, Raman; Petäistö, Tiina; Liu, Hengshuo; Kim, Kris S.; Karppinen, Sanna-Maria; Ruotsalainen, Heli; Koivunen, Jarkko; Mäki, Joni M.; Walker, Gilbert C.; Pihlajaniemi, Taina; Gullberg, Elon Donald; Heljasvaara, Ritva Leena (Journal article; Peer reviewed, 2022)
      Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated ...