Blar i Faculty of Medicine på tidsskrift "PLoS Biology"

Viser treff 1-3 av 3

    • Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation 

      Kumpula, Esa-Pekka; Lopez Moreno, Andrea Johana; Tajedin, Leila; Han, Huijong; Kursula, Inari (Peer reviewed; Journal article, 2019)
      Plasmodium actins form very short filaments and have a noncanonical link between ATP hydrolysis and polymerization. Long filaments are detrimental to the parasites, but the structural factors constraining Plasmodium ...

    • Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck 

      Edwards, David; Røyrvik, Ellen Christine; Chustecki, Joanne; Giannakis, Konstantinos; Glastad, Robert Clay; Radzvilavicius, Arunas; Johnston, Iain (Journal article; Peer reviewed, 2021)
      Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” ...

    • Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets 

      Petrenko, Volodymyr; Sinturel, Flore; Loizides-Mangold, Ursula; Montoya, Jonathan Paz; Chera, Simona; Riezman, Howard; Dibner, Charna (Journal article; Peer reviewed, 2022-08-03)
      Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian ...