Browsing Faculty of Medicine by Subject "3D cell cultures"

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Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture

Rajcevic, Uros; Knol, Jaco C; Piersma, Sander; Bougnaud, Sébastien; Fack, Fred; Sundlisæter, Eirik; Søndenaa, Karl; Myklebust, Reidar; Pham, Thang V.; Niclou, Simone P.; Jiménez, Connie R. (Peer reviewed; Journal article, 2014-07-11)

Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ...