Browsing Department of Biomedicine by Document Types "Master thesis"
Now showing items 41-60 of 90
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The in vitro effect of cytokine autoantibodies on Th17-differentiation and function
(Master thesis, 2023-06-01) -
In vitro study of a selective PI3K inhibitor on brain metastases
(Master thesis, 2020-06-17) -
The in vivo effect of integrin α11-deficiency and PDGFR inhibition in breast cancer
(Master thesis, 2018-10-19)Background: The tumor microenvironment is a major contributor to breast cancer progression. The abnormal composition of the extracellular matrix and its deregulated interactions with stromal cells, which is characterizing ... -
In vivo mapping of tumor microcirculation parameters using dynamic contrast enhanced MR imaging
(Master thesis, 2004) -
In-vitro characterization of STUB1 mutations in recessively inherited spinocerebellar ataxia-16
(Master thesis, 2016-05-31)Autosomal Recessive Cerebellar Ataxia (ARCA) develops as a result of inefficient protein turnover and further accumulation of damaged proteins inside the cells. Some of mutations associated with ARCA are identified in the ... -
Insights into the cellular role of Serine19 phosphorylation in tyrosine hydroxylase
(Master thesis, 2016-06-01)Tyrosine hydroxylase (TH) is the rate limiting enzyme that catalyzes the first step in the biosynthesis of catecholamines. The posttranslational modification of its regulatory domain controls the regulation of TH enzyme ... -
Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development
(Master thesis, 2024-06-03)Challenges in diagnosing and treating pancreatic cancer make it the fourth-leading cause of cancer-related deaths. Survival rates remain dismally low, and the molecular mechanisms driving this malignancy are still inadequately ... -
Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance
(Master thesis, 2018-06-29)Metastatic melanoma is a highly aggressive cancer with a very poor prognosis and current therapies remain inadequate. Norway is among the top five countries with the highest incidence of melanoma. Malignant cells carry ... -
Investigation of protein signalling pathways activated by sonoporation in cancer
(Master thesis, 2018-06-29)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ... -
Investigation of the apoptotic pathway in glioblastoma in the context of suicide gene therapy
(Master thesis, 2023-06-01)Glioblastoma is a highly malignant, aggressive and most common primary brain tumor in adults. Tremendous research efforts have been conducted in the field of GBM treatment discovery and succcess has only been achieved at ... -
Investigation of the Role of BCR/ABL1 in Neutrophil Extracellular Trap (NET) Formation in Chronic Myeloid Leukemia (CML)
(Master thesis, 2022-06-01)Neutrophil extracellular traps (NETs) represent a rather newly discovered antimicrobial mechanism first described by Brinkmann and co-workers in 2004. NETs are extracellular structures composed of decondensed chromatin ... -
LPS quantification of oral samples from the RHINESSA study population
(Master thesis, 2023-06-01)The human immune system defends the body against threats through a complex network of organs, cells, and proteins. It has two subsystems: the innate immune system provides immediate defense, while the adaptive immune system ... -
Making in vivo models viable again: Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Master thesis, 2019-06-28)Non-Homologous End-Joining (NHEJ) is the major DNA repair pathway that senses, processes and ligates DNA double strand breaks (DSBs) in higher eukaryotes, functionally throughout the cell cycle. The NHEJ involves four core ... -
Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis
(Master thesis, 2012-06-01)The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). ... -
Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression
(Master thesis, 2023-06-01)Stiffness regulation within the tumour microenvironment plays a pivotal role in tumorigenesis. In this context, integrin α11β1 is a collagen receptor expressed on cancer-associated fibroblasts (CAFs) involved in matrix ... -
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(Master thesis, 2012-05-30)Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ... -
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(Master thesis, 2009-08-02)Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Novel aspects of carboxyl ester lipase (CEL). Investigations on transcriptional regulation and tissue expression
(Master thesis, 2024-06-03)Carboxyl ester lipase (CEL) is a digestive enzyme that breaks down dietary fats in the duodenum, and it is mainly expressed by the pancreas and lactating mammary glands. A pathogenic variant of the CEL gene, named CEL-HYB1, ...