Browsing Department of Biomedicine by Title
Now showing items 505-524 of 753
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Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting
(Peer reviewed; Journal article, 2010-11)Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ... -
Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer
(Peer reviewed; Journal article, 2015-08-14)Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ... -
A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly
(Peer reviewed; Journal article, 2019-06-07)Background N-terminal acetylation is a common protein modification in human cells and is catalysed by N-terminal acetyltransferases (NATs), mostly cotranslationally. The NAA10-NAA15 (NatA) protein complex is the major NAT, ... -
A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines
(Peer reviewed; Journal article, 2015-09-08)To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2015-01)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2014-10-30)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ... -
Nuclear Receptor Genes - Regulation and Evolution
(Doctoral thesis, 2016-02-26)Nuclear receptors are transcription factors that typically bind ligands in order to regulate the expression level of their target genes. Members of this family work with their co-regulators and repressors to maintain a ... -
Nutritional properties of protein sources on diet-induced obesity, hepatic lipid accumulation, and fatty acid composition in mice
(Doctoral thesis, 2018-10-26)The prevalence of obesity has increased rapidly, and excess adiposity is associated with comorbidities that increase the risk of mortality. An energy-dense diet that is high in sugar and fat is one of the major explanations ... -
Occupational issues of adults with ADHD
(Peer reviewed; Journal article, 2013-02-17)Background: ADHD is a common neurodevelopmental disorder that persists into adulthood. Its symptoms cause impairments in a number of social domains, one of which is employment. We wish to produce a consensus statement on ... -
OLS Client and OLS Dialog: Open source tools to annotate public omics datasets
(Peer reviewed; Journal article, 2017)The availability of user‐friendly software to annotate biological datasets and experimental details is becoming essential in data management practices, both in local storage systems and in public databases. The Ontology ... -
On the Effect of DCE MRI Slice Thickness and Noise on Estimated Pharmacokinetic Biomarkers – A Simulation Study
(Journal article; Peer reviewed, 2020)Simulation of a dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) multiple sclerosis brain dataset is described. The simulated images in the implemented version have 1×1×1mm3 voxel resolution and arbitrary ... -
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
(Journal article; Peer reviewed, 2021)H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. This understanding may guide ... -
Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells
(Journal article; Peer reviewed, 2022)Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the ... -
Online interactive analysis of protein structure ensembles with Bio3D-web
(Peer reviewed; Journal article, 2016-11)Bio3D-web is an online application for analyzing the sequence, structure and conformational heterogeneity of protein families. Major functionality is provided for identifying protein structure sets for analysis, their ... -
Oral microbiome in a general population - The influence of sample site and sampling method
(Master thesis, 2023-08-02)Oral microbiome profiles reflect the sample types and methodology used to investigate them. The composition of microbes in the oral cavity is site specific. It can also vary due to differences in how a site is sampled. ... -
An overview of deep learning in medical imaging focusing on MRI
(Peer reviewed; Journal article, 2018-12-13)What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started ... -
An overview on G protein-coupled receptor-induced signal transduction in acute myeloid leukemia
(Peer reviewed; Journal article, 2019)Background: Acute Myeloid Leukemia (AML) is a genetically heterogeneous disease characterized by uncontrolled proliferation of precursor myeloid-lineage cells in the bone marrow. AML is also characterized by patients with ... -
Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts
(Peer reviewed; Journal article, 2017-08-23)Background: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and ... -
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
(Journal article; Peer reviewed, 2021)Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ... -
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
(Journal article; Peer reviewed, 2021)Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in ...