Blar i Department of Biomedicine på forfatter "Raasakka, Arne"
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Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
Nguyen, Giang Thi Tuyet; Sutinen, Aleksi; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri (Journal article; Peer reviewed, 2021)Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ... -
Structure of the mouse acidic amino acid decarboxylase GADL1
Raasakka, Arne; Mahootchi, Elaheh; Winge, Ingeborg; Luan, Weisha; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2018)Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ... -
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
Myllykoski, Matti; Sutinen, Aleksi; Koski, M. Kristian; Kallio, Juha Pekka; Raasakka, Arne; Myllyharju, Johanna; Wierenga, Rik K.; Koivunen, Peppi (Journal article; Peer reviewed, 2021)Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H—the poorly characterized endoplasmic ...