Blar i Department of Biomedicine på tittel
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Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts
(Peer reviewed; Journal article, 2017-08-23)Background: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and ... -
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
(Journal article; Peer reviewed, 2021)Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ... -
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
(Journal article; Peer reviewed, 2021)Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in ... -
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
(Journal article; Peer reviewed, 2023)PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its ... -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
(Journal article; Peer reviewed, 2020)Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived ... -
PeptideShaker Online: A User-Friendly Web-Based Framework for the Identification of Mass Spectrometry-Based Proteomics Data
(Journal article; Peer reviewed, 2021)Mass spectrometry-based proteomics is a high-throughput technology generating ever-larger amounts of data per project. However, storing, processing, and interpreting these data can be a challenge. A key element in simplifying ... -
The Peripheral Binding of 14-3-3γ to Membranes Involves Isoform-Specific Histidine Residues
(Peer reviewed; Journal article, 2012-11-26)Mammalian 14-3-3 protein scaffolds include seven conserved isoforms that bind numerous phosphorylated protein partners and regulate many cellular processes. Some 14-3-3-isoforms, notably γ, have elevated affinity for ... -
Personality traits, risk factors and comorbidities in Attention-deficit/hyperactivity disorder
(Doctoral thesis, 2020-06-19)Background: Attention-deficit/hyperactivity disorder (ADHD) comprises cognitive and behavioural traits present from childhood. During lifespan, people with ADHD are more prone to develop psychiatric- and somatic comorbidities ... -
Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia—A Focus on Tyrosine Hydroxylase Deficiency
(Journal article; Peer reviewed, 2021)Dopa-responsive dystonia (DRD) is a rare movement disorder associated with defective dopamine synthesis. This impairment may be due to the fact of a deficiency in GTP cyclohydrolase I (GTPCHI, GCH1 gene), sepiapterin ... -
PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin
(Journal article; Peer reviewed, 2020)The actin cytoskeleton is of profound importance to cell shape, division, and intracellular force generation. Profilins bind to globular (G-)actin and regulate actin filament formation. Although profilins are well-established ... -
Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid
(Journal article; Peer reviewed, 2021)The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent ... -
A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria
(Peer reviewed; Journal article, 2019-12-03)Mutations in hydroxymethylbilane synthase (HMBS) cause acute intermittent porphyria (AIP), an autosomal dominant disease where typically only one HMBS allele is mutated. In AIP, the accumulation of porphyrin precursors ... -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ... -
Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
(Peer reviewed; Journal article, 2012-09-26)Background: Legionella pneumophila is a pathogenic bacterium that can cause Legionnaires’ disease and other non-pneumonic infections in humans. This bacterium produces a pyomelanin pigment, a potential virulence factor ... -
Phosphatidylserine receptors enhance SARS-CoV-2 infection
(Journal article; Peer reviewed, 2021)Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by ... -
Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
(Journal article; Peer reviewed, 2020)The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is ... -
Phospholipase D in human blood platelets
(Doctoral thesis, 2008-05-30)We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLDs function in cells. ... -
Phosphorylation at serine 31 targets tyrosine hydroxylase tovesicles for transport along microtubules
(Peer reviewed; Journal article, 2017)Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine into L-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death ... -
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
(Journal article; Peer reviewed, 2022)PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ... -
PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
(Peer reviewed; Journal article, 2017-02)Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric ...