Browsing Department of Biomedicine by Author "Zhang, Xun"
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Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma
Zhang, Xun; Yao, Zhong; Xue, Zhiyi; Wang, Shuai; Liu, Xuemeng; Hu, Yaotian; Zhang, Yan; Wang, Jian; Li, Xingang; Chen, Anjing (Journal article; Peer reviewed, 2022)Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ... -
Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib
Yao, Zhong; Zhang, Xun; Zhao, Feihu; Wang, Shuai; Chen, Anjing; Huang, Bin; Wang, Jian; Li, Xingang (Journal article; Peer reviewed, 2020)Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ... -
Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
Liu, Xuemeng; Hu, Yaotian; Xue, Zhiyi; Zhang, Xun; Liu, Xiaofei; Liu, Guowei; Wen, Muzi; Chen, Anjing; Huang, Bin; Li, Xingang; Yang, Ning; Wang, Jian (Journal article; Peer reviewed, 2023)Background Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a ...