Browsing Department of Biomedicine by Subject "751910"
Now showing items 1-20 of 87
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3D Modelling of Brain Metastasis Microenvironment for Evaluation of Tumour-Stromal Interactions
(Master thesis, 2023-06-01)Brain metastases (BM) occur when cancer cells from the primary location spread to the brain through the bloodstream. BM affects approximately 20-40 % of cancer patients, with the majority originating from lung, breast, and ... -
Activated NK cells are potent effectors against glioblastoma cells due to activating KIR2DS2 and KIR2DS4 - HLA ligand interactions - In vitro study
(Master thesis, 2013-06-03)Background: Glioblastoma (GBM) is the most malignant brain tumor, where patients' median survival is only 14,6 months after diagnosis, thus novel, effective adjuvant therapies are required. Natural Killer (NK) cells are ... -
Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease. Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice
(Master thesis, 2017)The overarching goal of this project was to help elucidate how some of the molecular mechanisms behind memory and learning differ between healthy brains and those with neurodegenerative diseases, specifically by studying ... -
Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ... -
Arsenic exposure and developmental neurotoxicity: An evaluation of biomarkers of effect.
(Master thesis, 2022-08-01) -
Assessment of Image Quality of a PET/CT scanner for a Standarized Image situation Using a NEMA Body Phantom. “The impact of Different Image Reconstruction Parameters on Image quality”
(Master thesis, 2013-09-01)Radiologists and medical practitioners are working daily with images from integrated Positron Emission Tomography/ Computed Tomography (PET/CT) scanners in order to detect potentially lethal diseases. It is thus very ... -
Association between the number of CAG repeats in polymerase gamma and Parkinson disease in the Norwegian population
(Master thesis, 2012-06-01)Parkinson disease (PD) is a common neurodegenerative movement disorder that increases in prevalence with age. It is characterized clinically by resting tremor, rigidity, bradykinesia, and failing balance, and is due to the ... -
Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes
(Master thesis, 2012-07-01)Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and death ... -
Biochemical and biophysical characterisation of HMBS variants associated with acute intermittent porphyria
(Master thesis, 2022-06-01) -
Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin
(Master thesis, 2014-01-18)Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ... -
CEL in pancreatic disease: Do alcohol and smoking have an effect on the CEL-HYB1 protein?
(Master thesis, 2020-06-23) -
Cellular clearance and protein binding partners of pathogenic CEL-HYB
(Master thesis, 2022-06-01)The CEL gene encodes the digestive enzyme carboxyl ester lipase, which is mainly expressed in the acinar cells of the pancreas. In 2015, our research group discovered a CEL hybrid gene, named CEL-HYB, resulting from ... -
Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection
(Master thesis, 2009-06-02)Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ... -
Characterization and Tracking of Melanoma and Lung Brain Metastasis-Derived Extracellular Vesicles in vitro
(Master thesis, 2024-06-03)Brain metastasis (BM) occurs when cancer cells from a primary tumor elsewhere in the body spread to the brain. It poses significant challenges in cancer treatment due to its aggressive nature and limited therapeutic options, ... -
CHARACTERIZATION OF IMMUNE CELL SUBSETS IN A MODEL DISEASE FOR ENDOCRINE AUTOIMMUNITY BY MASS AND FLOW CYTOMETRY
(Master thesis, 2022-06-01)The autoimmune polyendocrine syndrome type 1 (APS1) is a complex and rare monogenic form of autoimmunity caused by pathogenic variants of the autoimmune regulator (AIRE) gene; a transcription factor primarily expressed in ... -
Characterization of Melanoma Brain Metastasis Cell Lines
(Master thesis, 2019-06-03)Brain metastasis is a major public health problem. Metastatic brain tumors are ten times more common than that of all other primary brain tumors combined. The estimated annual incidence in Europe is around 1.5 million cases ... -
Characterization of the renal function in Epac1 (RapGef3) knockout mice
(Master thesis, 2014-06-03)The discovery of the exchange proteins directly activated by cAMP (Epac) has renewed our knowledge of intracellular cAMP signaling. The Epac1 isoform (RapGef3) shows high expression level in the kidney. In vitro studies ... -
Dendritic cells in Sjögren's syndrome-functional analyses
(Master thesis, 2009-06-02)Sjögren's syndrome (SS) is an autoimmune disease of unknown etiology. It is characterized by chronic inflammation of the exocrine glands which leads to dryness of the mouth and eyes. Dendritic cells (DC) are the most potent ... -
Design of tumor-specific immunotherapies using dendritic cells - effect of bromelain on dendritic cell maturation
(Master thesis, 2009-06-02)Immunotherapy using dendritic cells (DC) has shown promising results in clinical trials, but few relevant successes are recorded. Therefore, the choice of an appropriate DC population is critical for the outcome of this ...