Blar i Department of Biomedicine på forfatter "Zehe, Markus"
-
Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Bothe, Sebastian; Hänzelmann, Petra; Böhler, Stephan; Kehrein, Josef; Zehe, Markus; Wiedemann, Christoph; Hellmich, Ute A.; Brenk, Ruth; Schindelin, Hermann; Sotriffer, Christoph (Journal article; Peer reviewed, 2022)Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for ...