Browsing Department of Biomedicine by Journals "Journal of Physiology"
Now showing items 1-4 of 4
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Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice
(Peer reviewed; Journal article, 2014-01)Collagen XV and XVIII are ubiquitous constituents of basement membranes. We aimed to study the physiological roles of these two components of the permeability barrier non-invasively in striated muscle in mice deficient in ... -
Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches
(Peer reviewed; Journal article, 2017-12)For most therapeutic antibodies, the interstitium is the target space. Although experimental methods for measuring antibody pharmacokinetics (PK) in this space are not well established, thus making quantitative assessment ... -
Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis
(Journal article; Peer reviewed, 2020)Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ... -
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
(Journal article; Peer reviewed, 2022)Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ...