Blar i Department of Global Public Health and Primary Care på forfatter "Nilsen, Rune"
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Characterization of an amorphous deposit in the lamina propria in oral snuff users in the Sudan as collagen
Idris, Ali M.; Warnakulasuriya, K. A. A. Saman; Ibrahim, Y. E.; Hartley, R.; Paterson, K.; Patel, B.; Nilsen, Rune; Johnson, N. W. (Peer reviewed; Journal article, 1998-04)Histological and ultrastructural features of 25 oral snuff dipper's lesions with distinctive subepithelial hyaline deposits were investigated. Periodic acid-Schiff reaction with and without diastase digestion demonstrated ... -
Immunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Sweden
Ibrahim, Salah Osman; Johannessen, Anne Christine; Idris, Ali M.; Hirsch, Jan M.; Vasstrand, Endre N.; Magnusson, Bengt; Nilsen, Rune (Journal article, 1996)Immunohistochemistry was used to examine the expression of p53 in pre-malignant oral lesions and oral squamous-cell carcinomas (SCCs) from Swedish and Sudanese snuff-dippers, as well as in pre-malignant oral lesions and ... -
In Situ Expression of CD40, CD40L (CD154), IL-12, TNF-a, IFN-g and TGF-b1 in Murine Lungs during Slowly Progressive Primary Tuberculosis
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Journal article; Peer reviewed, 2003-09)The distribution and expression of CD40, its ligand CD40L (154) and related cytokines interleukin-12 (IL-12), tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and transforming growth factor-β1 (TGF-β1) were studied ... -
In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 2000-06)The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first ... -
In situ localization of interferons in psoriatic lesions
Livden, J. K.; Nilsen, Rune; Matre, R. (Peer reviewed; Journal article, 1989-10)An indirect immunofluorescence technique, using murine monoclonal antibodies (MoAbs) against human IFN- and human IFN- was used to study IFNs in cryostat sections from psoriatic skin lesions. The IFNs were more pronounced ... -
Increased Bcl-2 and Reduced Bax Expression in Infected Macrophages in Slowly Progressive Primary Murine Mycobacterium tuberculosis Infection
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Peer reviewed; Journal article, 2002-10)Mycobacterium tuberculosis (MTB) persists in host macrophages (Mφs) because it has developed mechanisms to escape Mφ killing. In vitro studies have shown that MTB can induce and inhibit apoptosis by causing the expression ... -
Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection
Mustafa, Tehmina; Bjune, Gunnar Aksel; Jonsson, Roland; Pando, R. Hernandez; Nilsen, Rune (Peer reviewed; Journal article, 2001-12)To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ... -
A Mouse Model for Latent Tuberculosis
Phyu, S.; Mustafa, Tehmina; Hofstad, T.; Nilsen, Rune; Fosse, R.; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 1998-06)The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens ... -
A Mouse Model for Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Journal article, 1999-08)The progression from primary Mycobacterium tuberculosis infection to disease is usually slow in humans. The aim of this study was to develop and characterize a mouse model for slowly progressive primary tuberculosis, using ... -
Mutations of the p53 gene in oral squamous-cell carcinomas from sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers from the Sudan and Scandinavia
Ibrahim, Salah Osman; Vasstrand, Endre N.; Johannessen, Anne Christine; Idris, Ali M.; Magnusson, Bengt; Nilsen, Rune; Lillehaug, Johan (Journal article, 1999-11-08)Using PCR-SSCP/DNA sequencing methods, we analyzed 14 oral squamous-cell carcinomas (OSCCs) and 8 pre-malignant oral lesions from different Sudanese patients for prevalence of mutations in exons 5 to 9 of the p53 gene in ... -
The role of livestock keeping in tuberculosis trends in Arusha, Tanzania
Mfinanga, Sayoki Godfrey; Mørkve, Odd; Kazwala, R. R.; Cleaveland, S.; Sharp, J. M.; Shirima, G.; Nilsen, Rune (Peer reviewed; Journal article, 2003-07)SETTING: Arusha, Tanzania. OBJECTIVE: To assess risk factors that might influence TB control in the general population and in livestock-keepers. METHODS: Of 242 villages in four districts, 27 were selected randomly. In ... -
The Swedish Snus and the Sudanese Toombak: are they different?
Idris, Ali M.; Ibrahim, Salah Osman; Vasstrand, Endre N.; Johannessen, Anne Christine; Lillehaug, Johan; Magnusson, Bengt; Wallström, M.; Hirsch, Jan M.; Nilsen, Rune (Journal article, 1998-11)In Sweden, snuff (locally known as snus), was introduced since the year 1637. Presently, Sweden has the highest per capita consumption and sale figures of snuff in the world, and the habit is becoming increasingly popular. ... -
Toombak Use and Cigarette Smoking in the Sudan: Estimates of Prevalence in the Nile State
Idris, Ali M.; Ibrahim, Y. E.; Warnakulasuriya, K. A. A. Saman; Cooper, D. J.; Johnson, N. W.; Nilsen, Rune (Peer reviewed; Journal article, 1998-07)Background. Survey data on the prevalence of use of oral snuff (toombak) and cigarette consumption according to various demographic factors are needed in the Sudan. Methods. A house to house cross-sectional survey of a ... -
Tribal differences in perception of tuberculosis : a possible role in tuberculosis control in Arusha, Tanzania
Mfinanga, Sayoki Godfrey; Mørkve, Odd; Kazwala, R. R.; Cleaveland, S.; Sharp, J. M.; Shirima, G.; Nilsen, Rune (Peer reviewed; Journal article, 2003-10)SETTING: Arusha, Tanzania. OBJECTIVE: To determine tribal differences in knowledge and practices that might influence tuberculosis control. METHOD: Twenty-seven villages were selected randomly out of 242 villages in four ...