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dc.contributor.authorSkuladottir, Hilduren_US
dc.contributor.authorWilcox, Allen Jamesen_US
dc.contributor.authorMa, Chenen_US
dc.contributor.authorLammer, Edward J.en_US
dc.contributor.authorRasmussen, Sonja A.en_US
dc.contributor.authorWerler, Martha M.en_US
dc.contributor.authorShaw, Gary M.en_US
dc.contributor.authorCarmichael, Suzan L.en_US
dc.description.abstractBackground: Maternal use of corticosteroids during early pregnancy has been inconsistently associated with orofacial clefts in the offspring. A previous report from the National Birth Defect Prevention Study (NBDPS), using data from 1997 to 2002, found an association with cleft lip and palate (odds ratio, 1.7; 95% confidence interval [CI], 1.1–2.6), but not cleft palate only (odds ratio, 0.5, 95%CI, 0.2–1.3). From 2003 to 2009, the study population more than doubled in size, and our objective was to assess this association in the more recent data. Methods: The NBDPS is an ongoing multi-state populationbased case-control study of birth defects, with ascertainment of cases and controls born since 1997. We assessed the association of corticosteroids and orofacial clefts using data from 2372 cleft cases and 5922 controls born from 2003 to 2009. Maternal corticosteroid exposure was based on telephone interviews. Results: The overall association of corticosteroids and cleft lip and palate in the new data was 1.0 (95% CI, 0.7–1.4). There was little evidence of associations between specific corticosteroid components or timing and clefts. Conclusion: In contrast to the 1997 to 2002 data from the NBDPS, the 2003 to 2009 data show no association between maternal corticosteroid use and cleft lip and palate in the offspring.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subjectorofacial cleftseng
dc.subjectcleft lip and palateeng
dc.subjectbirth defectseng
dc.titleCorticosteroid use and risk of orofacial cleftsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authors
dc.source.journalBirth defects research. Clinical and molecular teratology

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