dc.contributor.author | Wiren, Sara | en_US |
dc.contributor.author | Häggström, Christel | en_US |
dc.contributor.author | Ulmer, Hanno | en_US |
dc.contributor.author | Manjer, Jonas | en_US |
dc.contributor.author | Bjørge, Tone | en_US |
dc.contributor.author | Nagel, Gabriele | en_US |
dc.contributor.author | Johansen, Dorthe | en_US |
dc.contributor.author | Hallmans, Göran | en_US |
dc.contributor.author | Engeland, Anders | en_US |
dc.contributor.author | Concin, Hans | en_US |
dc.contributor.author | Jonsson, Håkan | en_US |
dc.contributor.author | Selmer, Randi | en_US |
dc.contributor.author | Tretli, Steinar | en_US |
dc.contributor.author | Stocks, Tanja | en_US |
dc.contributor.author | Stattin, Pär | en_US |
dc.date.accessioned | 2015-03-12T10:07:30Z | |
dc.date.available | 2015-03-12T10:07:30Z | |
dc.date.issued | 2013-10-31 | eng |
dc.identifier.issn | 0957-5243 | |
dc.identifier.issn | 1573-7225 | |
dc.identifier.uri | https://hdl.handle.net/1956/9522 | |
dc.description.abstract | Purpose: To assess the association between height and risk of cancer and cancer death. Methods: The metabolic syndrome and cancer project is a prospective pooled cohort study of 585,928 participants from seven cohorts in Austria, Norway, and Sweden. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for cancer incidence and death were estimated in height categories and per 5-cm increment for each cancer site using Cox proportional hazards model. Results: During a mean follow-up of 12.7 years (SD = 7.2), 38,862 participants were diagnosed with cancer and 13,547 participants died of cancer. Increased height (per 5-cm increment) was associated with an increased overall cancer risk in women, HR 1.07 (95 % CI 1.06–1.09), and in men, HR 1.04 (95 % CI 1.03–1.06). The highest HR was seen for malignant melanoma in women, HR 1.17 (95 % CI 1.11–1.24), and in men HR 1.12 (95 % CI 1.08–1.19). Height was also associated with increased risk of cancer death in women, HR 1.03 (95 % CI 1.01–1.16), and in men, HR 1.03 (95 % CI 1.01–1.05). The highest HR was observed for breast cancer death in postmenopausal women (>60 years), HR 1.10 (95 % CI 1.00–1.21), and death from renal cell carcinoma in men, HR 1.18 (95 % CI 1.07–1.30). All these associations were independent of body mass index. Conclusion: Height was associated with risk of cancer and cancer death indicating that factors related to height such as hormonal and genetic factors stimulate both cancer development and progression. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Springer International Publishing | eng |
dc.relation.uri | http://download.springer.com/static/pdf/659/art%253A10.1007%252Fs10552-013-0317-7.pdf?auth66=1392207675_76a6d20d9752566a979117fddc83d843&ext=.pdf | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | Body stature | eng |
dc.subject | Body height | eng |
dc.subject | Epidemiology | eng |
dc.subject | Cancer risk | eng |
dc.subject | Cohort study | eng |
dc.title | Pooled cohort study on height and risk of cancer and cancer death | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-03-05T09:19:35Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright The Author(s) 2013. This article is published with open access at Springerlink.com | |
dc.identifier.doi | https://doi.org/10.1007/s10552-013-0317-7 | |
dc.identifier.cristin | 1076331 | |
dc.source.journal | Cancer Causes and Control | |
dc.source.40 | 25 | |
dc.source.14 | 2 | |
dc.source.pagenumber | 151-159 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Oncology: 762 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 | nob |