Vis enkel innførsel

dc.contributor.authorRongsen-Chandola, Temsunaroen_US
dc.contributor.authorStrand, Tor A.en_US
dc.contributor.authorGoyal, Nidhien_US
dc.contributor.authorFlem, Elmiraen_US
dc.contributor.authorSingh Rathore, Sudeepen_US
dc.contributor.authorArya, Aloken_US
dc.contributor.authorWinje, Brita Askelanden_US
dc.contributor.authorLazarus, Robinen_US
dc.contributor.authorShanmugasundaram, Elangoen_US
dc.contributor.authorBabji, Sudhiren_US
dc.contributor.authorSommerfelt, Halvoren_US
dc.contributor.authorVainio, Kirstien_US
dc.contributor.authorKang, Gagandeepen_US
dc.contributor.authorBhandari, Nitaen_US
dc.description.abstractInterference from transplacental and breast milk antibodies may impede the performance of oral livevaccines. The effect of breastfeeding on the immunogenicity of Rotarix®, a two-dose oral monova-lent rotavirus vaccine, was examined in a community-based trial in New Delhi, India. Four hundredmother–infant pairs were randomized into two equal groups. Infants were aged 6–7 weeks at enroll-ment. Mothers were encouraged to either breastfeed or to withhold breastfeeding during the 30 minprior to and after each vaccine dose was administered. We collected blood specimens from infants atenrollment and 4 weeks after the second vaccine dose. Blood and breast milk specimens were obtainedfrom mothers at baseline and breast milk specimens were collected at the time of the second vaccinedose. Seroconversion was defined as infant serum anti-VP6 IgA antibody level of ≥20 IU/mL 4 weeksafter the second vaccine dose and a ≥4-fold rise from baseline. There was no difference in the propor-tion who seroconverted between the two groups (26% vs 27%; p = 0.92). The levels of infant serum IgA,maternal serum and breast milk IgA and IgG anti-rotavirus antibodies predicted the anti-rotavirus IgAlevel in infants at end-study and explained approximately 10% of the variability of the immune response(r2= 0.10, p < 0.001). In this population, the immune response to Rotarix®was not enhanced by withholding breastfeedingaround the time of vaccination. Maternal anti-rotavirus antibodies explained little of the variability in theimmune response to the vaccine. Factors other than maternal anti-rotavirus antibodies probably explainwhy infants in low-and middle-income settings respond poorly to live oral rotavirus vaccines.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subjectimmune responseeng
dc.subjectwithhold breastfeedingeng
dc.subjectencouraged breastfeedingeng
dc.titleEffect of withholding breastfeeding on the immune response to a live oral rotavirus vaccine in North Indian infantsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 Published by Elsevier Ltd.
dc.source.14Suppl. 1
dc.relation.projectNorges forskningsråd: 223269
dc.subject.nsiVDP::Medical sciences: 700::Health sciences: 800::Preventive medicine: 804eng
dc.subject.nsiVDP::Medical sciences: 700::Health sciences: 800::Health service and health administration research: 806eng
dc.subject.nsiVDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716eng
dc.subject.nsiVDP::Medical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801eng
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Forebyggende medisin: 804nob
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806nob
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716nob
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801nob

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-NoDerivs CC BY-NC-ND
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivs CC BY-NC-ND