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dc.contributor.authorCharlton, Rachel A.en_US
dc.contributor.authorNeville, Amanda J.en_US
dc.contributor.authorJordan, Sueen_US
dc.contributor.authorPierini, Annaen_US
dc.contributor.authorDamase-Michel, Christineen_US
dc.contributor.authorKlungsøyr, Karien_US
dc.contributor.authorAndersen, Anne-Marie Nyboen_US
dc.contributor.authorHansen, Anne Vinkelen_US
dc.contributor.authorGini, Rosaen_US
dc.contributor.authorBos, Jens H.J.en_US
dc.contributor.authorPuccini, Auroraen_US
dc.contributor.authorHurault-Delarue, Carolineen_US
dc.contributor.authorBrooks, Caroline J.en_US
dc.contributor.authorDe Jong-van den Berg, Lolkje T.V.en_US
dc.contributor.authorde Vries, Corinne S.en_US
dc.description.abstractPurpose The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. Methods A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. Results Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. Conclusion This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest. © 2014 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subjectelectronic medical recordseng
dc.subjectautomated dataeng
dc.titleHealthcare databases in Europe for studying medicine use and safety during pregnancyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authors
dc.source.journalPharmacoepidemiology and Drug Safety
dc.subject.nsiVDP::Medical sciences: 700::Health sciences: 800::Health service and health administration research: 806eng
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806nob

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