BORA - UiB

Bergen Open Research Archive

In Situ Expression of CD40, CD40L (CD154), IL-12, TNF-a, IFN-g and TGF-b1 in Murine Lungs during Slowly Progressive Primary Tuberculosis

Bergen Open Research Archive

Show simple item record

dc.contributor.author Mogga, S. J.
dc.contributor.author Mustafa, Tehmina
dc.contributor.author Sviland, Lisbet
dc.contributor.author Nilsen, Rune
dc.date.accessioned 2007-01-09T14:02:24Z
dc.date.available 2007-01-09T14:02:24Z
dc.date.issued 2003-09
dc.identifier.citation Scandinavian Journal of Immunology 2003 58(3): 327–334
dc.identifier.issn 0300-9475
dc.identifier.issn 1365-3083
dc.identifier.uri http://dx.doi.org/10.1046/j.1365-3083.2003.01304.x
dc.identifier.uri http://hdl.handle.net/1956/2054
dc.description.abstract The distribution and expression of CD40, its ligand CD40L (154) and related cytokines interleukin-12 (IL-12), tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and transforming growth factor-β1 (TGF-β1) were studied in the lungs of B6D2F1 hybrid mice during slowly progressive primary tuberculosis (TB) by immunohistochemistry. CD40 and CD40L are implicated in cell-mediated immunity (CMI) causing activation or apoptosis of infected cells. The phenomenon of apoptosis is associated with Mycobacterium tuberculosis survival. In this study, using frozen lung sections (n = 33), our results showed increased CD40, IL-12 and TGF-β1 expression in macrophages with progression of disease. High percentages of mycobacterial antigens (M.Ags), CD40L and IFN-γ expression were maintained throughout infection, and TNF-α-expressing cells were decreased. In lymphocytes, the percentage of IFN-γ-positive cells was increased, but CD40L and IL-12 were maintained with the progression of disease. M.Ags, CD40 and CD40L were expressed in the same areas of the lesions. We conclude that changes in the expression of CD40–CD40L and cytokines associated with M. tuberculosis infection favour the hypothesis that M. tuberculosis causes resistance of host cells to apoptosis causing perpetuation of infection. en
dc.format.extent 1071705 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher Blackwell Publishing Ltd. en
dc.rights Copyright 2003 Blackwell Publishing Ltd.
dc.title In Situ Expression of CD40, CD40L (CD154), IL-12, TNF-a, IFN-g and TGF-b1 in Murine Lungs during Slowly Progressive Primary Tuberculosis en
dc.type Journal article en
dc.type Peer reviewed
dc.subject.nsi VDP::Medisinske Fag: 700::Helsefag: 800 no
dc.subject.nsi VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 no
dc.type.version publishedVersion


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Search BORA


Browse

My Account