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Characterization of an amorphous deposit in the lamina propria in oral snuff users in the Sudan as collagen

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dc.contributor.author Idris, Ali M.
dc.contributor.author Warnakulasuriya, K. A. A. Saman
dc.contributor.author Ibrahim, Y. E.
dc.contributor.author Hartley, R.
dc.contributor.author Paterson, K.
dc.contributor.author Patel, B.
dc.contributor.author Nilsen, Rune
dc.contributor.author Johnson, N. W.
dc.date.accessioned 2007-03-18T17:18:14Z
dc.date.available 2007-03-18T17:18:14Z
dc.date.issued 1998-04
dc.identifier.citation Journal of Oral Pathology & Medicine 1998 27(4): 157-62
dc.identifier.issn 0904-2512
dc.identifier.uri http://hdl.handle.net/1956/2156
dc.identifier.uri http://dx.doi.org/10.1111/j.1600-0714.1998.tb01933.x en
dc.description.abstract Histological and ultrastructural features of 25 oral snuff dipper's lesions with distinctive subepithelial hyaline deposits were investigated. Periodic acid-Schiff reaction with and without diastase digestion demonstrated the presence of glycogen and other carbohydrates, but histochemical stains for normal collagen, elastin and fibrin showed a weak variable reactivity of the deposit. Although in 7/25 cases the deposit was in close proximity to labial salivary glands and on occasions ducts were found within the deposit, the presence of mucin was not a consistent feature. Congo red staining and immunohistochemical investigation with an anti-amyloid antibody did not support the previous contention that such deposits were amyloid in nature. Immunohistochemically, collagen antibodies also provided negative results, but ultrastructural features of three biopsies studied suggest that the bulk of this deposit is made up of collagen, as typical cross-striated fibrils were found. The pathogenesis of this deposit could therefore be interpreted as over-production and/or reduced turnover of collagen by resident fibroblasts, which is further altered by the ingredients of toombak. The deposit does not appear to be a secretory product. en
dc.format.extent 546560 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher Munksgaard en
dc.rights Copyright 1998 Munksgaard en
dc.title Characterization of an amorphous deposit in the lamina propria in oral snuff users in the Sudan as collagen en
dc.type Journal article en
dc.type Peer reviewed en
dc.subject.nsi VDP::Medisinske Fag: 700 en
dc.subject.nsi VDP::Medisinske Fag: 700::Helsefag: 800 en


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