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Immunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Sweden

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dc.contributor.author Ibrahim, Salah Osman
dc.contributor.author Johannessen, Anne Christine
dc.contributor.author Idris, Ali M.
dc.contributor.author Hirsch, Jan M.
dc.contributor.author Vasstrand, Endre N.
dc.contributor.author Magnusson, Bengt
dc.contributor.author Nilsen, Rune
dc.date.accessioned 2007-03-18T17:52:11Z
dc.date.available 2007-03-18T17:52:11Z
dc.date.issued 1996
dc.identifier.citation International Journal of Cancer 68(6): 749-753
dc.identifier.issn 0020-7136
dc.identifier.uri http://dx.doi.org/10.1002/(SICI)1097-0215(19961211)68:6<749::AID-IJC10>3.0.CO;2-W
dc.identifier.uri http://hdl.handle.net/1956/2157
dc.description.abstract Immunohistochemistry was used to examine the expression of p53 in pre-malignant oral lesions and oral squamous-cell carcinomas (SCCs) from Swedish and Sudanese snuff-dippers, as well as in pre-malignant oral lesions and oral SCCs from non-snuff-dippers from the Sudan, Sweden and Norway. Of the 14 SCCs from Sudanese snuff-dippers, 21% (3/14) expressed p53. Of the 14, 60 and 41 SCCs from non-snuff-dippers from the Sudan, Sweden and Norway, 64% (9/14), 65% (39/60) and 68% (28/41) expressed p53, respectively. A statistically significant difference in expression of p53 was found in SCCs from Sudanese snuff-dippers compared to those from non-snuff-dippers from all/or any of the 3 countries. None of the suspected pre-malignant oral lesions from Sudanese snuff dippers or non-snuff-dippers expressed p53. Only 2 out of the 15 oral fibro-epithelial hyperplastic lesions from Swedish snuff-dippers expressed p53. Some of the oral epithelial dysplastic lesions, as well as the carcinoma in situ lesions from Norwegian non-snuffdippers, expressed p53, while the oral fibro-epithelial hyperplastic lesions did not. The low relative frequency of p53 expression found in oral SCCs from snuff-dippers compared to those from non-snuff-dippers might suggest differences in mechanisms of oncogenic action induced by snuff. Alternatively, the pathogenesis of malignant oral lesions from snuff-dippers may follow a p53-independent pathway. In view of the unusually high levels of the tobacco-specific nitrosamines (TSNA) found in the type of snuff used in the Sudan, investigations of p53 mutations or oncogenes are needed. en
dc.format.extent 741197 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher Wiley-Liss, Inc. en
dc.rights Copyright 1996 Wiley-Liss, Inc.
dc.title Immunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Sweden en
dc.type Journal article en
dc.type Peer reviewed
dc.subject.nsi VDP::Medisinske Fag: 700 no
dc.subject.nsi VDP::Medisinske Fag: 700::Helsefag: 800 no


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