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dc.contributor.authorIbrahim, Salah Osmaneng
dc.contributor.authorJohannessen, Anne Christineeng
dc.contributor.authorIdris, Ali M.eng
dc.contributor.authorHirsch, Jan M.eng
dc.contributor.authorVasstrand, Endre N.eng
dc.contributor.authorMagnusson, Bengteng
dc.contributor.authorNilsen, Runeeng
dc.date.accessioned2007-03-18T17:52:11Z
dc.date.available2007-03-18T17:52:11Z
dc.date.issued1996eng
dc.identifier.citationInternational Journal of Cancer 68(6): 749-753
dc.identifier.issn0020-7136eng
dc.identifier.urihttp://hdl.handle.net/1956/2157
dc.description.abstractImmunohistochemistry was used to examine the expression of p53 in pre-malignant oral lesions and oral squamous-cell carcinomas (SCCs) from Swedish and Sudanese snuff-dippers, as well as in pre-malignant oral lesions and oral SCCs from non-snuff-dippers from the Sudan, Sweden and Norway. Of the 14 SCCs from Sudanese snuff-dippers, 21% (3/14) expressed p53. Of the 14, 60 and 41 SCCs from non-snuff-dippers from the Sudan, Sweden and Norway, 64% (9/14), 65% (39/60) and 68% (28/41) expressed p53, respectively. A statistically significant difference in expression of p53 was found in SCCs from Sudanese snuff-dippers compared to those from non-snuff-dippers from all/or any of the 3 countries. None of the suspected pre-malignant oral lesions from Sudanese snuff dippers or non-snuff-dippers expressed p53. Only 2 out of the 15 oral fibro-epithelial hyperplastic lesions from Swedish snuff-dippers expressed p53. Some of the oral epithelial dysplastic lesions, as well as the carcinoma in situ lesions from Norwegian non-snuffdippers, expressed p53, while the oral fibro-epithelial hyperplastic lesions did not. The low relative frequency of p53 expression found in oral SCCs from snuff-dippers compared to those from non-snuff-dippers might suggest differences in mechanisms of oncogenic action induced by snuff. Alternatively, the pathogenesis of malignant oral lesions from snuff-dippers may follow a p53-independent pathway. In view of the unusually high levels of the tobacco-specific nitrosamines (TSNA) found in the type of snuff used in the Sudan, investigations of p53 mutations or oncogenes are needed.en
dc.format.extent741197 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherWiley-Liss, Inc.eng
dc.titleImmunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Swedeneng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske Fag: 700nob
dc.subject.nsiVDP::Medisinske Fag: 700::Helsefag: 800nob
dc.rights.holderCopyright 1996 Wiley-Liss, Inc.
bibo.doihttp://dx.doi.org/10.1002/(SICI)1097-0215(19961211)68:6<749eng
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1097-0215(19961211)68:6<749


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