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Effects of Benzene on human hematopoiesis

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dc.contributor.author Kirkeleit, Jorunn
dc.contributor.author Riise, Trond
dc.contributor.author Gjertsen, Bjørn Tore
dc.contributor.author Moen, Bente E.
dc.contributor.author Bråtveit, Magne
dc.contributor.author Bruserud, Øystein
dc.date.accessioned 2011-02-09T14:04:31Z
dc.date.available 2011-02-09T14:04:31Z
dc.date.issued 2008
dc.identifier.citation The Open Hematology Journal 2: 87-102 en_US
dc.identifier.issn 1874-2769
dc.identifier.uri http://hdl.handle.net/1956/4487
dc.identifier.uri http://dx.doi.org/10.2174/1874276900802010087
dc.description.abstract Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals. en_US
dc.language.iso eng en_US
dc.publisher Bentham Open en
dc.rights Copyright Kirkeleit et al.; Licensee Bentham Open. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ en_US
dc.title Effects of Benzene on human hematopoiesis en_US
dc.type Peer reviewed en_US
dc.type Journal article en_US
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 en_US
dc.rightsHolder Kirkeleit et al. en_US
dc.type.version publishedVersion en_US
bora.cristinID 501346


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