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Effects of Benzene on human hematopoiesis

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dc.contributor.author Kirkeleit, Jorunn eng
dc.contributor.author Riise, Trond eng
dc.contributor.author Gjertsen, Bjørn Tore eng
dc.contributor.author Moen, Bente E. eng
dc.contributor.author Bråtveit, Magne eng
dc.contributor.author Bruserud, Øystein eng
dc.date.accessioned 2011-02-09T14:04:31Z
dc.date.available 2011-02-09T14:04:31Z
dc.date.issued 2008 eng
dc.identifier.citation The Open Hematology Journal 2: 87-102 en_US
dc.identifier.issn 1874-2769 eng
dc.identifier.uri http://hdl.handle.net/1956/4487
dc.description.abstract Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals. en_US
dc.language.iso eng eng
dc.publisher Bentham Open en
dc.rights Copyright Kirkeleit et al.; Licensee Bentham Open. eng
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ eng
dc.title Effects of Benzene on human hematopoiesis en_US
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 eng
dc.rightsHolder Kirkeleit et al. eng
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bora.cristinID 501346 eng
bibo.doi http://dx.doi.org/10.2174/1874276900802010087 eng
dc.identifier.doi http://dx.doi.org/10.2174/1874276900802010087


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