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Tuberculosis recurrence in smear-positive patients cured under DOTS in southern Ethiopia: retrospective cohort study

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dc.contributor.author Datiko, Daniel Gemechu eng
dc.contributor.author Lindtjørn, Bernt eng
dc.date.accessioned 2011-02-24T13:48:52Z
dc.date.available 2011-02-24T13:48:52Z
dc.date.issued 2009-09-18 eng
dc.identifier.citation BMC Public Health 9(348) en_US
dc.identifier.issn 1471-2458 eng
dc.identifier.uri http://hdl.handle.net/1956/4535
dc.description.abstract Background: Decentralization of DOTS has increased the number of cured smear-positive tuberculosis (TB) patients. However, the rate of recurrence has increased mainly due to HIV infection. Recurrence rate could be taken as an important measure of long-term success of TB treatment. We aimed to find out the rate of recurrence in smear-positive patients cured under DOTS in southern Ethiopia. Methods: We did a retrospective cohort study on cured smear-positive TB patients who were treated from 1998 to 2006. Recurrence of smear-positive TB was used as an outcome measure. Person-years of observation (PYO) were calculated per 100 PYO from the date of cure to date of interview. Kaplan-Meier and Cox-regression methods were used to determine the survival and the hazard ratio (HR). Results: 368 cured smear-positive TB patients which were followed for 1463 person-years. Of these, 187 patients (50.8%) were men, 277 patients (75.5%) were married, 157 (44.2%) were illiterate, and 152 patients (41.3%) were farmers. 15 of 368 smear-positive patients had recurrence. The rate of recurrence was 1 per 100 PYO (0.01 per annum). Recurrence was not associated with age, sex, occupation, marital status and level of education. Conclusion: High recurrence rate occurred among smear-positive patients cured under DOTS. Further studies are required to identify factors contributing to high recurrence rates to improve disease free survival of TB patients after treatment. en_US
dc.language.iso eng eng
dc.publisher BioMed Central eng
dc.rights Attribution CC BY eng
dc.rights.uri http://creativecommons.org/licenses/by/2.0 eng
dc.title Tuberculosis recurrence in smear-positive patients cured under DOTS in southern Ethiopia: retrospective cohort study eng
dc.type Journal article eng
dc.type Peer reviewed eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776 eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 eng
dc.rights.holder Copyright 2008 Datiko and Lindtjørn; licensee BioMed Central
dc.rights.holder Datiko and Lindtjørn eng
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bibo.doi http://dx.doi.org/10.1186/1471-2458-9-348 eng
dc.identifier.doi http://dx.doi.org/10.1186/1471-2458-9-348


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