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Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey

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dc.contributor.author Ndeezi, Grace
dc.contributor.author Tumwine, James K.
dc.contributor.author Bolann, Bjørn J.
dc.contributor.author Ndugwa, Christopher M.
dc.contributor.author Tylleskär, Thorkild
dc.date.accessioned 2011-04-14T07:00:36Z
dc.date.available 2011-04-14T07:00:36Z
dc.date.issued 2010-09-21
dc.identifier.citation BMC Pediatrics 10:68 en_US
dc.identifier.issn 1471-2431
dc.identifier.uri http://dx.doi.org/10.1186/1471-2431-10-68
dc.identifier.uri http://hdl.handle.net/1956/4658
dc.description.abstract Background Low concentrations of serum zinc have been reported in HIV infected adults and are associated with disease progression and an increased risk of death. Few studies have been conducted in HIV infected children in Africa. We determined serum zinc levels and factors associated with zinc deficiency in HIV infected Ugandan children. Methods We measured the baseline zinc status of 247 children aged 1-5 years enrolled in a randomised trial for multiple micronutrient supplementation at paediatric HIV clinics in Uganda (http://ClinicalTrials.gov webcite NCT00122941). Zinc status was determined using inductively coupled atomic emission spectrophotometry (ICP-AES). Clinical and laboratory characteristics were compared among zinc deficient (zinc < 10.0 μmol/L) and non deficient children. Logistic regression was used to determine predictors of low serum zinc. Results Of the 247 children, 134 (54.3%) had low serum zinc (< 10.0 μmol/L). Of the 44 children on highly active antiretroviral therapy (HAART), 13 (29.5%) had low zinc compared to 121/203 (59.6%) who were not on HAART. Overall, independent predictors of low zinc were fever (OR 2.2; 95%CI 1.1 - 4.6) and not taking HAART (OR 3.7; 95%CI 1.8 - 7.6). Conclusion Almost two thirds of HAART naïve and a third of HAART treated HIV infected children were zinc deficient. Increased access to HAART among HIV infected children living in Uganda might reduce the prevalence of zinc deficiency. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central en
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5153" target="_blank">Multiple micronutrient supplementation in HIV-infected children. A randomised trial among children aged 1-5 years in Uganda</a> en
dc.rights Copyright 2010 Ndeezi et al; licensee BioMed Central Ltd. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey en_US
dc.type Peer reviewed en_US
dc.type Journal article en_US
dc.subject.nsi VDP::Medical disciplines: 700 en_US
dc.rightsHolder Ndeezi et al. en_US
dc.type.version publishedVersion en_US
bora.cristinID 339224


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Copyright 2010 Ndeezi et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as Copyright 2010 Ndeezi et al; licensee BioMed Central Ltd.

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