Blar i Faculty of Medicine på tittel

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    • Identification and characterization of aptameric inhibitors of human neutrophil elastase 

      Malicki, Stanisław; Książek, Mirosław; Sochaj Gregorczyk, Alicja; Kaminska, Marta; Golda, Anna; Chruścicka, Barbara; Mizgalska, Danuta; Potempa, Jan; Marti, Hans Peter; Kozieł, Joanna; Wieczorek, Maciej; Pieczykolan, Jerzy; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2023)
      Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...

    • Identification and development of small molecule therapies for the treatment of acute myeloid leukaemia 

      Leitch, Calum (Doctoral thesis, 2022-02-11)
      Acute myeloid leukaemia (AML) is a cancer of the bone marrow in which immature myeloid cells exhibit uncontrolled proliferation and failure to differentiate. The global 5-year overall survival rate for AML ranges between ...

    • Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA 

      Dahlqvist, Johanna; Ekman, Diana; Sennblad, Bengt; Kozyrev, Sergey V.; Nordin, Jessika; Karlsson, Åsa; Meadows, Jennifer R. S.; Hellbacher, Erik; Rantapää-Dahlqvist, Solbritt; Berglin, Ewa; Stegmayr, Bernd; Haslund, Bo; Palm, Øyvind; Haukeland, Hilde; Gunnarsson, Iva; Bruchfeld, Annette; Segelmark, Mårten; Ohlsson, Sophie; Mohammad, Aladdin J.; Svärd, Anna Jessica; Pullerits, Rille; Herlitz, Hans; Söderbergh, Annika; Pielberg, Gerli Rosengren; Rosenberg, Lina Hultin; Bianchi, Matteo; Muren, Eva; Omdal, Roald; Jonsson, Roland; Eloranta, Maija-Leena; Rönnblom, Lars; Söderkvist, Peter; Knight, Ann; Eriksson, Per; Lindblad-Toh, Kerstin (Journal article; Peer reviewed, 2021)
      Objective To identify and characterize genetic loci associated with the risk of developing ANCA-associated vasculitides (AAV). Methods Genetic association analyses were performed after Illumina sequencing of 1853 genes ...

    • Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31 

      Permuth-Wey, Jennifer; Lawrenson, K; Shen, HC; Velkova, A; Tyrer, JP; Chen, ZH; Lin, HY; Chen, YA; Tsai, YY; Qu, XT; Ramus, SJ; Karevan, R; Lee, J; Lee, N; Larson, MC; Aben, KK; Anton-Culver, H; Antonenkova, N; Antoniou, AC; Armasu, SM; Bacot, F; Baglietto, L; Bandera, EV; Barnholtz-Sloan, J; Beckmann, MW; Birrer, MJ; Bloom, G; Bogdanova, N; Brinton, LA; Brooks-Wilson, A; Brown, R; Butzow, R; Cai, QY; Campbell, I; Chang-Claude, J; Chanock, S; Chenevix-Trench, G; Cheng, JQ; Cicek, MS; Coetzee, GA; Cook, LS; Couch, FJ; Cramer, DW; Cunningham, JM; Dansonka-Mieszkowska, A; Despierre, E; Doherty, JA; Dork, T; du Bois, A; Durst, M; Easton, DF; Eccles, D; Edwards, R; Ekici, AB; Fasching, PA; Fenstermacher, DA; Flanagan, JM; Garcia-Closas, M; Gentry-Maharaj, A; Giles, GG; Glasspool, RM; Gonzalez-Bosquet, J; Goodman, MT; Gore, M; Gorski, B; Gronwald, J; Hall, P; Halle, Mari Kyllesø; Harter, P; Heitz, F; Hillemanns, P; Hoatlin, M; Hogdall, CK; Hogdall, E; Hosono, S; Jakubowska, A; Jensen, A; Jim, H; Kalli, KR; Karlan, BY; Kaye, SB; Kelemen, LE; Kiemeney, LA; Kikkawa, F; Konecny, GE; Krakstad, Camilla; Kjaer, SK; Kupryjanczyk, J; Lambrechts, D; Lambrechts, S; Lancaster, JM; Le, ND; Leminen, A; Levine, DA; Liang, D; Lim, BK; Lin, J; Lissowska, J; Lu, KH; Lubinski, J; Lurie, G; Massuger, LFAG; Matsuo, K; McGuire, V; McLaughlin, JR; Menon, U; Modugno, F; Moysich, KB; Nakanishi, T; Narod, SA; Nedergaard, L; Ness, RB; Nevanlinna, H; Nickels, S; Noushmehr, H; Odunsi, K; Olson, SH; Orlow, I; Paul, J; Pearce, CL; Pejovic, T; Pelttari, LM; Pike, MC; Poole, EM; Raska, P; Renner, SP; Risch, HA; Rodriguez-Rodriguez, L; Rossing, MA; Rudolph, A; Runnebaum, IB; Rzepecka, IK; Salvesen, Helga Birgitte; Schwaab, I; Severi, G; Shridhar, V; Shu, XO; Shvetsov, YB; Sieh, W; Song, HL; Southey, MC; Spiewankiewicz, B; Stram, D; Sutphen, R; Teo, SH; Terry, KL; Tessier, DC; Thompson, PJ; Tworoger, SS; van Altena, AM; Vergote, I; Vierkant, RA; Vincent, D; Vitonis, AF; Wang-Gohrke, S; Weber, RP; Wentzensen, N; Whittemore, AS; Wik, Elisabeth; Wilkens, LR; Winterhoff, B; Woo, YL; Wu, AH; Xiang, YB; Yang, HP; Zheng, W; Ziogas, A; Zulkifli, F; Phelan, CM; Iversen, E; Schildkraut, JM; Berchuck, A; Fridley, BL; Goode, EL; Pharoah, PDP; Monteiro, ANA; Sellers, TA; Gayther, SA (Peer reviewed; Journal article, 2013-03-27)
      Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ ...

    • Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection 

      El-Khoury, Victoria; Schritz, Anna; Kim, Sang-Yoon; Lesur, Antoine; Sertamo, Katriina; Bernardin, Francois; Petritis, Konstantinos; Pirrotte, Patrick; Selinsky, Cheryl; Whiteaker, Jeffrey R; Zhang, Haizhen; Kennedy, Jacob J; Lin, Chenwei; Lee, Lik Wee; Yan, Ping; Tran, Nhan L; Inge, Landon J; Chalabi, Khaled; Decker, Georges; Bjerkvig, Rolf; Paulovich, Amanda G; Berchem, Guy; Kim, Yeoun Jin (Journal article; Peer reviewed, 2020)
      Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ...

    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...

    • Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 

      Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article; Peer reviewed, 2020)
      Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ...

    • Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design 

      Irsheid, Lina; Wehler, Thomas; Borek, Christoph; Kiefer, Werner; Brenk, Ruth; Ortiz-Soto, Maria Elena; Seibel, Jurgen; Schirmeister, Tanja (Peer reviewed; Journal article, 2019-05-08)
      Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates ...

    • Identification of acute coronary syndrome in the era of high-sensitivity troponin assays 

      Steiro, Ole-Thomas (Doctoral thesis, 2023-06-02)
      Bakgrunn: Det er mulig å bedre pasientflyt og diagnostisk presisjon ved utredning av pasienter med mistenkt akutt koronarsyndrom (AKS). Konsentrasjonen av kardialt troponin (cTnT eller cTnI) kan benyttes til å forutse ...

    • Identification of biomarkers for glycaemic deterioration in type 2 diabetes 

      Slieker, Roderick C.; Donnelly, Louise A.; Akalestou, Elina; Lopez-Noriega, Livia; Melhem, Rana; Güneş, Ayşim; Abou Azar, Frederic; Efanov, Alexander; Georgiadou, Eleni; Muniangi-Muhitu, Hermine; Sheikh, Mahsa; Giordano, Giuseppe N.; Åkerlund, Mikael; Ahlqvist, Emma; Ali, Ashfaq; Banasik, Karina; Brunak, Søren; Barovic, Marko; Bouland, Gerard A.; Burdet, Frédéric; Canouil, Mickaël; Dragan, Iulian; Elders, Petra J. M.; Fernandez, Celine; Festa, Andreas; Fitipaldi, Hugo; Froguel, Phillippe; Gudmundsdottir, Valborg; Gudnason, Vilmundur; Gerl, Mathias J.; van der Heijden, Amber A.; Jennings, Lori L.; Hansen, Michael K.; Kim, Min; Leclerc, Isabelle; Klose, Christian; Kuznetsov, Dmitry; Mansour Aly, Dina; Mehl, Florence; Marek, Diana; Melander, Olle; Niknejad, Anne; Ottosson, Filip; Pavo, Imre; Duffin, Kevin; Syed, Samreen K.; Shaw, Janice L.; Cabrera, Over; Pullen, Timothy J.; Simons, Kai; Solimena, Michele; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W.; Lim, Gareth E.; Estall, Jennifer; Ibberson, Mark; Beulens, Joline W. J.; ’t Hart, Leen M; Pearson, Ewan R.; Rutter, Guy A. (Journal article; Peer reviewed, 2023)
      We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ...

    • Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis 

      Kong, Yang; Xue, Zhiwei; Wang, Haiying; Cui, Guangqiang; Chen, Anjing; Liu, Jie; Wang, Jian; Li, Xingang; Huang, Bin (Journal article; Peer reviewed, 2022)
      Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ...

    • Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism 

      Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Urióstegui-Pena, Andrea G.; Srivastava, Aashish; Aguilar-Marcelino, Liliana; Iqbal, Hafiz M. N.; Ahmed, Shiek S. S. J.; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2023-04-25)
      The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ...

    • Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach 

      Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2023)
      Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ...

    • Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania 

      Moyo, Sabrina John; Maselle, Samwel Y.; Matee, Mecky I.; Langeland, Nina; Mylvaganam, Haima (Peer reviewed; Journal article, 2007-08-09)
      Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ...

    • Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy 

      Markunas, Christina A; Xu, Zongli; Harlid, Sophia; Wade, Paul A.; Lie, Rolv Terje; Taylor, Jack A.; Wilcox, Allen James (Peer reviewed; Journal article, 2014-10-01)
      Background: Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have ...

    • Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid 

      Opsahl, Jill Anette; Ljostveit, Sonja; Saunders, Threrese Solstad; Risa, Kristin; Roepstorff, Peter; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2013)
      Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ...

    • Identification of gait domains and key gait variables following hip fracture 

      Thingstad, Pernille; Egerton, Thorlene; Ihlen, Espen F; Taraldsen, Kristin; Moe-Nilssen, Rolf; Helbostad, Jorunn L (Peer reviewed; Journal article, 2015-11-18)
      Background Restoration of gait is an important goal of rehabilitation after hip fracture. Numerous spatial and temporal gait variables have been reported in the literature, but beyond gait speed, there is little agreement ...

    • Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment 

      O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ...

    • Identification of genetic loci shared between schizophrenia and the Big Five personality traits 

      Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr; Witoelar, Aree; Tesli, Martin Steen; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2017-05-22)
      Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between ...

    • Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder 

      O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ...