Browsing Faculty of Medicine by Title
Now showing items 8487-8506 of 8812
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Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway
(Journal article; Peer reviewed, 2022)Background and Objectives. Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease, characterized by gradual paralysis and muscle atrophy. Riluzole, the only approved treatment in Norway, increases mean ... -
Use of patient-reported outcome measures (PROMs) in clinical diabetes consultations: study protocol for the DiaPROM randomised controlled trial pilot study
(Peer reviewed; Journal article, 2019)Introduction: Although diabetes distress is found to be associated with decreased glycaemic control among adults with type 1 diabetes, the psychological and emotional impact of living with the condition is often not ... -
Use of patient-reported outcome measures (PROMs) in clinical diabetes consultations: the DiaPROM randomised controlled pilot trial
(Journal article; Peer reviewed, 2021)Objective: To pilot test the proposed DiaPROM trial components and address uncertainties associated with conducting a full-scale randomised controlled trial (RCT) to evaluate whether such a trial is feasible. Design: ... -
Use of probiotics to reduce infections and death and prevent colonization with extended-spectrum beta-lactamase (ESBL)- producing bacteria among newborn infants in Tanzania (ProRIDE Trial): study protocol for a randomized controlled clinical trial
(Journal article; Peer reviewed, 2021)Background Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has emerged as an urgent global health threat and is by the World Health Organization ranked as priority 1 among pathogens in need of new ... -
The use of prosthetic grafts in above-knee femoropopliteal bypass surgery : a clinical study of long-term results and risk factors for failure
(Doctoral thesis, 2007-05-24)Purpose: The purpose of this study has been to investigate the results of above-knee prosthetic femoropopliteal bypass surgery and to identify risk factors for complications and graft failure. The influence of comorbidity, ... -
Use of quantitative pathology to improve grading and predict prognosis in tumours of the gastrointestinal tract
(Doctoral thesis, 2022-01-14)Cancer represents a formidable health burden and was the second leading cause of death globally in 2018. In Norway, almost 35000 new cancer cases were reported in 2019. For colon cancer, the incidence and mortality rates ... -
Use of References in Responses from Scandinavian Drug Information Centres
(Journal article, 2018)Background: The aim of this study was to compare use of references in responses from Scandinavian drug information centres (DICs). Methods: Six different fictitious drug-related queries were sent to each of seven Scandinavian ... -
Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia
(Journal article; Peer reviewed, 2021)Introduction For phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, the only approved indication in women is for pulmonary arterial hypertension. These drugs are increasingly being proposed and tested for ... -
Use of social media for communicating about critical care topics: A Norwegian cross-sectional survey
(Peer reviewed; Journal article, 2019-07-08)Background: Social media (SoMe) might be an alternative platform for communicating critical care topics to implement evidence‐based practice in the intensive care unit (ICU). This survey aims to describe ICU nurses’ and ... -
Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins
(Peer reviewed; Journal article, 2012)In this manuscript, we present a proof-of-concept study for targeted relative protein quantitation workflow using chemical labeling in the form of dimethylation, coupled with selected reaction monitoring (dimethyl-SRM). ... -
Usefulness of manipulative therapy of the upper cervical joints in patients with cervicogenic headache - a single system experimental study
(Master thesis, 2010-10-28)Summary of background data: Cervicogenic headache is considered as the third most common headache form by some researchers. Manual therapists diagnose and treat these patients. Cervical manipulative therapy is a treatment ... -
User Involvement in Myasthenia Gravis Research
(Journal article; Peer reviewed, 2022-06-02) -
Using Growth velocity to predict child mortality
(Peer reviewed; Journal article, 2016)Background: Growth assessment based on the WHO child growth velocity standards can potentially be used to predict adverse health outcomes. Nevertheless, there are very few studies on growth velocity to predict mortality. ... -
Using induced pluripotent stem cells for modeling POLG mitochondrial disease : Stamceller som modellsystem for å behandle mitokondriesykdom
(Doctoral thesis, 2022-02-03)Background: More than 90% of the energy required to sustain life is provided by mitochondria through the process of oxidative phosphorylation (OXPHOS). The role of mitochondria, however, is not restricted to supplying ... -
Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder
(Journal article; Peer reviewed, 2021)Schizophrenia (SCZ) and bipolar disorder (BIP) are severe mental disorders with a considerable disease burden worldwide due to early age of onset, chronicity, and lack of efficient treatments or prevention strategies. ... -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ... -
Using mass spectrometry-based proteomics to improve the understanding of multiple sclerosis treatments
(Doctoral thesis, 2021-06-23)In this work, the effects of multiple sclerosis (MScl) treatments were investigated by quantitative proteomics. First, the effects of the anti-inflammatory drug Fingolimod was studied to see if the drug affected central ... -
Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study
(Peer reviewed; Journal article, 2019-04-26)Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ... -
Using Patient-Reported Outcome Measures (PROMs) in clinical diabetes consultations : Feasibility testing and piloting the DiaPROM trial among adults with type 1 diabetes
(Doctoral thesis, 2021-09-09)Background: The demands of type 1 diabetes (T1D) may constitute a great burden for people living with the disease. Diabetes distress reflects a range of emotional experiences, such as worry, guilt, and fear, potentially ... -
Using patient-reported outcome measures for improved decision-making in patients with gastrointestinal cancer – the last clinical frontier in surgical oncology?
(Peer reviewed; Journal article, 2013-06-14)The genomic era has introduced concepts of “personalized medicine” and “targeted therapy” in the field of oncology. Medicine has become increasingly complex with a plethora of potential dilemmas in diagnosis, treatment, ...