Blar i Faculty of Medicine på tittel
Viser treff 81-100 av 8754
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Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines
(Peer reviewed; Journal article, 2017-04-17)Anthracyclines are key components of human breast cancer chemotherapy. Here, we explored the role of Akt signaling in anthracycline resistance. The antitumor activity of doxorubicin and Akt inhibitor A-443654 alone or ... -
Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells
(Peer reviewed; Journal article, 2012-03-27)Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ... -
Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
(Journal article; Peer reviewed, 2022)Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ... -
The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells
(Peer reviewed; Journal article, 2015-04-13)Introduction: Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sumof tamoxifen and all itsmetabolites. 4-Hydroxytamoxifen ... -
Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients
(Journal article; Peer reviewed, 2022-09-19)Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with no validated specific and sensitive biomarker, and no standard approved treatment. In this observational study with no intervention, ... -
The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication
(Peer reviewed; Journal article, 2010-01-27)Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation ... -
Actual clinical leadership: a shadowing study of charge nurses and doctors on-call in the emergency department
(Peer reviewed; Journal article, 2019-01-08)Background: The provision of safe, high quality healthcare in the Emergency Department (ED) requires frontline healthcare personnel with sufficient competence in clinical leadership. However, healthcare education curriculum ... -
Acute bronchiolitis in infants, a review
(Peer reviewed; Journal article, 2014-04-03)Acute viral bronchiolitis is one of the most common medical emergency situations in infancy, and physicians caring for acutely ill children will regularly be faced with this condition. In this article we present a summary ... -
Acute cerebral infarcts in multiple arterial territories : The Bergen NORSTROKE study
(Doctoral thesis, 2020-09-18)Introduction The majority of acute cerebral infarcts results from an occlusion of one single cerebral artery followed by loss of blood supply to the respective arterial territory. However, several independent arterial ... -
Acute chest pain - A prospective population based study of contacts to Norwegian emergency medical communication centres
(Peer reviewed; Journal article, 2011-07-21)Background: Acute chest pain is a frequently occurring symptom in patients with medical emergencies and imposes potentially life threatening situations outside hospitals. Little is known about the epidemiology of patients ... -
Acute complications of spinal cord injuries
(Peer reviewed; Journal article, 2015)The aim of this paper is to give an overview of acute complications of spinal cord injury (SCI). Along with motor and sensory deficits, instabilities of the cardiovascular, thermoregulatory and broncho-pulmonary system are ... -
Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial
(Peer reviewed; Journal article, 2019-10-22)Background: Fish protein hydrolysates are suggested to contain bioactive sequences capable of affecting metabolic pathways involved in the regulation of glucose metabolism and body weight when consumed in low doses. ... -
Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat
(Peer reviewed; Journal article, 2011-07-12)This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of ... -
Acute effects of whey protein on energy intake, appetite and gastric emptying in younger and older, obese men
(Journal article; Peer reviewed, 2020)Background Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, ... -
Acute elevation of intra-abdominal pressure contributes to extravascular shift of fluid and proteins in an experimental porcine model
(Peer reviewed; Journal article, 2014-10-20)Background: Intra-abdominal hypertension and abdominal compartment syndrome contribute significantly to increased morbidity and mortality in critically ill patients. This study describes pathophysiologic effects of the ... -
Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma
(Journal article; Peer reviewed, 2020)Rationale There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to ... -
Acute hospital admissions - a registry-based study of general practitioners’ and out-of-hours doctors’ roles as gatekeepers in Norway
(Doctoral thesis, 2023-02-03)For pasienter med akutte medisinske tilstander er det viktig å ha tilgang til nødvendige helsetjenester. I mange lands helsetjeneste må pasientene vurderes av en primærleger før innleggelse i sykehus, og dermed fungerer ... -
Acute hospital admissions among nursing home residents: a population-based observational study
(Peer reviewed; Journal article, 2011-05-26)Background: Nursing home residents are prone to acute illness due to their high age, underlying illnesses and immobility. We examined the incidence of acute hospital admissions among nursing home residents versus the ... -
Acute hospital admissions from nursing homes. Rates and characteristics; unwarranted variation and effects of interventions to reduce them
(Doctoral thesis, 2014-02-28)Background: The geriatric nursing home population is vulnerable to acute incidences in their health condition, due to longevity, multiple chronic illnesses and a low level of physical and mental function. Aims: The overall ... -
Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators
(Journal article; Peer reviewed, 2021)Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) gene, which encodes the third enzyme in the haem ...