Blar i Faculty of Medicine på forfatter "Karlsen, Marie"
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Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome
Vogelsang, Petra; Karlsen, Marie; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2014-08-11)Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ... -
The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2012-02-21)Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ... -
Design of tumor-specific immunotherapies using dendritic cells - effect of bromelain on dendritic cell maturation
Karlsen, Marie (Master thesis, 2009-06-02)Immunotherapy using dendritic cells (DC) has shown promising results in clinical trials, but few relevant successes are recorded. Therefore, the choice of an appropriate DC population is critical for the outcome of this ... -
Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome
Karlsen, Marie; Hansen, Torbjørn; Nordal, Hilde Haugedal; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2015-03-19)Introduction: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an ... -
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke (Peer reviewed; Journal article, 2011-01-05)Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ...