Blar i Department of Biomedicine på tittel
Viser treff 91-110 av 775
-
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
(Journal article; Peer reviewed, 2022)Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ... -
CEL in pancreatic disease: Do alcohol and smoking have an effect on the CEL-HYB1 protein?
(Master thesis, 2020-06-23) -
Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action
(Peer reviewed; Journal article, 2015-10-22)Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the ... -
CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation
(Peer reviewed; Journal article, 2013-08-09)The application of fluorescence microscopy in cell biology often generates a huge amount of imaging data. Automated whole cell segmentation of such data enables the detection and analysis of individual cells, where a manual ... -
Cellular clearance and protein binding partners of pathogenic CEL-HYB
(Master thesis, 2022-06-01)The CEL gene encodes the digestive enzyme carboxyl ester lipase, which is mainly expressed in the acinar cells of the pancreas. In 2015, our research group discovered a CEL hybrid gene, named CEL-HYB, resulting from ... -
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma
(Peer reviewed; Journal article, 2017-09-25)The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but ... -
Cellular Host Responses to Gliomas
(Peer reviewed; Journal article, 2012-04-23)Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular ... -
Cellular responses to metabolic stress. A study on the role of mitochondria in the crosstalk between cell metabolism and survival signaling
(Doctoral thesis, 2012-08-31)Metabolic imbalance is associated with increased risk of several diseases, including cancer. Metabolism affects or is affected by virtually all other cellular processes, which is not surprising considering their conserved ... -
Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis
(Journal article; Peer reviewed, 2021-02-18)Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ... -
Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy
(Journal article; Peer reviewed, 2021)Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment ... -
Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT - A Systematic Review
(Journal article; Peer reviewed, 2022)The kynurenine pathway of tryptophan (Trp) metabolism generates multiple biologically active metabolites (kynurenines) that have been implicated in neuropsychiatric disorders. It has been suggested that modulation of ... -
Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function
(Journal article; Peer reviewed, 2022)Hydroxymethylbilane synthase (HMBS) is the third enzyme involved in haem biosynthesis, in which it catalyses the formation of tetrapyrrole 1-hydroxymethylbilane (HMB). In this process, HMBS binds four consecutive substrate ... -
Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection
(Master thesis, 2009-06-02)Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ... -
Characterization and Tracking of Melanoma and Lung Brain Metastasis-Derived Extracellular Vesicles in vitro
(Master thesis, 2024-06-03)Brain metastasis (BM) occurs when cancer cells from a primary tumor elsewhere in the body spread to the brain. It poses significant challenges in cancer treatment due to its aggressive nature and limited therapeutic options, ... -
The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach
(Doctoral thesis, 2019-04-12)Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively). Myelin insulates axons, which increases nerve conduction ... -
CHARACTERIZATION OF IMMUNE CELL SUBSETS IN A MODEL DISEASE FOR ENDOCRINE AUTOIMMUNITY BY MASS AND FLOW CYTOMETRY
(Master thesis, 2022-06-01)The autoimmune polyendocrine syndrome type 1 (APS1) is a complex and rare monogenic form of autoimmunity caused by pathogenic variants of the autoimmune regulator (AIRE) gene; a transcription factor primarily expressed in ... -
Characterization of Melanoma Brain Metastasis Cell Lines
(Master thesis, 2019-06-03)Brain metastasis is a major public health problem. Metastatic brain tumors are ten times more common than that of all other primary brain tumors combined. The estimated annual incidence in Europe is around 1.5 million cases ... -
Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
(Journal article; Peer reviewed, 2021)Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute ... -
Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes
(Peer reviewed; Journal article, 2019-08-01)Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ... -
Characterization of the PLP-dependent decarboxylases GADL1 and CSAD
(Doctoral thesis, 2022-03-31)Pyridoxal 5’-phosphate (PLP) -dependent enzymes constitute an essential superfamily of enzymes for all living organisms. Due to the chemistry of their cofactor, PLP, these enzymes catalyze a wide variety of reactions. ...