Browsing Bergen Open Research Archive by Title
Now showing items 11950-11969 of 34165
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Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
(Journal article; Peer reviewed, 2022)The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of genetic risk factors in autoimmune Addison’s disease
(Doctoral thesis, 2020-10-23)Autoimmune diseases occur when the immune system attacks and damages the body’s own tissue. Why people develop these diseases, and how the autoimmune reaction develops are unanswered questions. Autoimmune Addison's disease ... -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional connectome differences in individuals with hallucinations across the psychosis continuum
(Journal article; Peer reviewed, 2021)Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit ... -
Functional Data Analysis of Non-manual Marking of Questions in Kazakh-Russian Sign Language
(Chapter, 2022)This paper is a continuation of Kuznetsova et al. (2021), which described non-manual markers of polar and wh-questions in comparison with statements in an NLP dataset of Kazakh-Russian Sign Language (KRSL) using Computer ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Functional evaluation and work participation in health care workers with musculoskeletal disorders
(Doctoral thesis, 2016-06-22)Background: In Norway and other western countries, musculoskeletal disorders (MSDs) are the most frequent reasons for sick leave and disability pensions, and particularly employees in the health and social sector have a ... -
Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro
(Journal article; Peer reviewed, 2021)Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ... -
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ... -
Functional Gastrointestinal Disorders following Giardia infection : Visceral hypersensitivity and low-grade inflammation
(Doctoral thesis, 2020-10-20)Background: Giardia lamblia is a non-invasive protozoan parasite, infecting mainly the upper small intestine. It is the most common cause of waterborne outbreaks of diarrhea in an endemic country. The first registered ... -
Functional imaging to promote individualized and targeted therapy in endometrial cancer
(Doctoral thesis, 2016-02-05)Background: Endometrial carcinoma is the most common pelvic malignancy in the Western world and the incidence is increasing. Endometrial carcinomas are surgically staged according to FIGO 2009 criteria, and the lack of ... -
Functional inequalities on path space of sub-Riemannian manifolds and applications
(Journal article; Peer reviewed, 2021)We consider the path space of a manifold with a measure induced by a stochastic flow with an infinitesimal generator that is hypoelliptic, but not elliptic. These generators can be seen as sub-Laplacians of a sub-Riemannian ... -
Functional investigations of the Ecdysone Receptor and production of ecdysone in the salmon louse (Lepeophtheirus salmonis)
(Doctoral thesis, 2016-05-24)The salmon louse Lepeophtheirus salmonis is a marine ectoparasitic copepod naturally infecting salmonid fishes in the Northern hemisphere. At present, salmon louse infections are the most severe disease problem in the ... -
Functional level after Traumatic Brain Injury
(Doctoral thesis, 2012-02-03)Objectives: The objectives of the thesis were to describe the functional level (papers I and II) and self awareness of functional deficits (paper III) after moderate and severe Traumatic Brain Injury (TBI), and to evaluate ... -
Functional Level During the First Year After Moderate and Severe Traumatic Brain Injury: Course and Predictors of Outcome
(Peer reviewed; Journal article, 2011-06)Background: The objective of this study was to describe the functional level during the first year after moderate and severe traumatic brain injury (TBI), and to evaluate the predictive impact of pre-injury and injury-related ...